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Journal of Neurology
Published in: Journal of Neurology 3/2020

Open Access 01-03-2020 | Tremor | Review

Zona incerta as a therapeutic target in Parkinson’s disease

Author: Krystyna Ossowska

Published in: Journal of Neurology | Issue 3/2020

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Abstract

The zona incerta has recently become an important target for deep-brain stimulation (DBS) in Parkinson’s disease (PD). The present review summarizes clinical, animal and anatomical data which have indicated an important role of this structure in PD, and discusses potential mechanisms involved in therapeutic effects of DBS. Animal studies have suggested initially some role of neurons as well as GABAergic and glutamatergic receptors of the zona incerta in locomotion and generation of PD signs. Anatomical data have indicated that thanks to its multiple interconnections with the basal ganglia, thalamus, cerebral cortex, brainstem, spinal cord and cerebellum, the zona incerta is an important link in a neuronal chain transmitting impulses involved in PD pathology. Finally, clinical studies have shown that DBS of this structure alleviates parkinsonian bradykinesia, muscle rigidity and tremor. DBS of caudal zona incerta seemed to be the most effective therapeutic intervention, especially with regard to reduction of PD tremor as well as other forms of tremor.
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Metadata
Title
Zona incerta as a therapeutic target in Parkinson’s disease
Author
Krystyna Ossowska
Publication date
01-03-2020
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 3/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-019-09486-8

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