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Published in: Journal of Neurology 6/2019

01-06-2019 | Insomnia | Original Communication

Non-motor symptoms in Huntington’s disease: a comparative study with Parkinson’s disease

Authors: Tatiana Aldaz, Pasquale Nigro, Almudena Sánchez-Gómez, Celia Painous, Lluís Planellas, Pilar Santacruz, Ana Cámara, Yaroslau Compta, Francesc Valldeoriola, Maria J. Martí, Esteban Muñoz

Published in: Journal of Neurology | Issue 6/2019

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Abstract

Background/aims

The presence of non-motor symptoms in Huntington’s disease (HD) has not been systematically assessed so far. Our objective was to know their prevalence and to compare it with a cohort of patients with Parkinson’s disease (PD).

Materials and methods

Participants were consecutively recruited from our outpatient clinic. They were assessed through the motor part of the Unified Huntington’s Disease Rating Scale, the motor part of the Unified Parkinson’s Disease Rating Scale, the total functional capacity scale and the PD non-motor symptoms questionnaire.

Results

We enrolled 123 participants: 53 HD, 45 PD and 25 healthy controls (HC). Non-motor symptoms were significantly more prevalent in HD patients than in HC. The most frequent non-motor symptoms in HD, involving more than 50% of patients, were attentional deficits, apathy, dysphagia, memory complaints, depression falls, insomnia and urinary urgency. The total score of non-motor symptoms correlated with disease duration, total functional capacity and disease stage. HD scored significantly higher than PD in 11 items (dysphagia, constipation, bowel incontinence, faecal tenesmus, weight loss, memory, apathy, attention, falls, nightmares, delusions) and in four domains (cognitive, hallucinations and delusions, digestive and cardiovascular). PD did not score significantly higher than HD in any domain.

Conclusions

HD patients have a high prevalence of non-motor symptoms, which is even higher than in PD, and correlates with disease progression.
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Metadata
Title
Non-motor symptoms in Huntington’s disease: a comparative study with Parkinson’s disease
Authors
Tatiana Aldaz
Pasquale Nigro
Almudena Sánchez-Gómez
Celia Painous
Lluís Planellas
Pilar Santacruz
Ana Cámara
Yaroslau Compta
Francesc Valldeoriola
Maria J. Martí
Esteban Muñoz
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 6/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-019-09263-7

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