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01-02-2019 | Alzheimer's Disease | Original Communication

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study

Authors: Salvatore Mazzeo, Sonia Padiglioni, Silvia Bagnoli, Laura Bracco, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi

Published in: Journal of Neurology | Issue 2/2019

Abstract

The aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). For this purpose, we followed up 263 patients (154 SCD; 109 MCI) for a mean time of 7 years. CR was assessed by the Test di Intelligenza Breve (TIB), functionally equivalent to the National Adult Reading Test. High CR resulted as a protective factor for progression from SCD to MCI. Age at conversion to MCI was delayed 9 years on average in SCD with high CR with respect to SCD with low CR. On the contrary, high CR resulted as a risk factor for progression from MCI to AD dementia only in APOE ε4 carriers. Conversion time from MCI to AD dementia was 3 years shorter in ε4 carriers with high CR than subjects with low CR and ε4 non-carriers with high CR. Consistent with the CR hypothesis, our results showed that higher levels of CR protect against the earliest clinical manifestations of AD. In line with the previous researches, we found an interaction between CR and APOE in progression from MCI to AD dementia.

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Title: The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study
Authors: Salvatore Mazzeo
Sonia Padiglioni
Silvia Bagnoli
Laura Bracco
Benedetta Nacmias
Sandro Sorbi
Valentina Bessi
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Keywords: Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Mild Cognitive Impairment
Published in: Journal of Neurology / Issue 2/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-9164-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study

Abstract

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