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Journal of Neurology

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Open Access 01-01-2018 | Original Communication

Changes in disability in people with multiple sclerosis: a 10-year prospective study

Authors: David Conradsson, Charlotte Ytterberg, Lena von Koch, Sverker Johansson

Published in: Journal of Neurology | Issue 1/2018

Abstract

Background

Little is known about the long-term course of disability in relation with disease severity in people with multiple sclerosis (PwMS).

Objective

To explore changes in a broad spectrum of disability over 10 years in relation with disease severity in PwMS.

Methods

We conducted a longitudinal study of 155 PwMS who attended the MS Centre at Karolinska University Hospital, Stockholm. Disease severity was determined by the use of the Expanded Disability Status Scale (EDSS) and classified as mild MS (EDSS score 0–3.5) or moderate/severe MS (EDSS score 4–9.5). Ten-year changes in perceived physical and psychological impacts of MS, walking, cognition, manual dexterity, participation in social/lifestyle activities, and signs of depression were compared between PwMS with mild and moderate/severe MS at baseline.

Results

Although walking, manual dexterity, and cognition declined in both groups, only the moderate/severe group demonstrated that long-term increased physical impact of MS, increased wheel-chair dependency, and reduced participation in social/lifestyle activities. Perceived psychological impact of MS declined in both groups, while signs of depression were experienced by fewer in the mild group and remained unaltered in the moderate/severe group.

Conclusion

We found a more pronounced increase in disability across 10 years in individuals with moderate/severe MS compared to mild MS. These findings accentuate the importance of developing a variety of interventions that can be applied across the spectrum of disease severity.

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Title: Changes in disability in people with multiple sclerosis: a 10-year prospective study
Authors: David Conradsson
Charlotte Ytterberg
Lena von Koch
Sverker Johansson
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 1/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-017-8676-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Changes in disability in people with multiple sclerosis: a 10-year prospective study

Abstract

Background

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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