Skip to main content
Top
Published in: Journal of Neurology 7/2017

01-07-2017 | Original Communication

Optimizing the deep brain stimulation care pathway in patients with Parkinson’s disease

Authors: N. J. Thomas, P. Mertens, T. Danaila, G. Polo, H. Klinger, E. Broussolle, S. Thobois

Published in: Journal of Neurology | Issue 7/2017

Login to get access

Abstract

Management of Parkinson’s disease (PD) using deep brain stimulation (DBS) requires complex care in specialized, multidisciplinary centers. A well-organized, efficient patient flow is crucial to ensure that eligible patients can quickly access DBS. Delays or inefficiencies in patient care may impact a center’s ability to meet demand, creating a capacity bottleneck. Analysis of the current practices within a center may help identify areas for improvement. After external audit of the DBS workflow of the Lyon Neurological Hospital and comparison with other European centers, manageable steps were suggested to restructure the care pathway. Propositions of the audit comprised, for example: (1) directly admitting referred patients to hospital, without a prior neurological outpatient visit and (2) including the preoperative anesthesia consultation in the hospital stay 1 month before surgery, not separately. This reorganization (between 2013 and 2016) was performed without increases in hospital medical resources or costs. The time from patients’ first referral to surgery was reduced (from 22 to 16 months; p = 0.033), as was the number of pre- and postoperative patient visits (11–5; p = 0.025) and the total cumulative length of in-hospital stay (20.5–17.5 nights; p = 0.02). Ultimately, the total number of PD consultations increased (346–498 per year), as did the number of DBS implants per year (32–45 patients). In this single center experience, restructuring the DBS care pathway allowed a higher number of PD patients to benefit from DBS therapy, with a shorter waiting time and without decreasing the quality of care.
Literature
1.
go back to reference Elbaz A, Carcaillon L, Kab S, Moisan F (2016) Epidemiology of Parkinson’s disease. Rev Neurol (Paris) 172(1):14–26CrossRef Elbaz A, Carcaillon L, Kab S, Moisan F (2016) Epidemiology of Parkinson’s disease. Rev Neurol (Paris) 172(1):14–26CrossRef
2.
go back to reference Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jönsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, Van den Bergh P, van Os J, Vos P, Xu W, Wittchen HU, Jönsson B, Olesen J, Group CS (2010) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10):718–779CrossRef Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jönsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, Van den Bergh P, van Os J, Vos P, Xu W, Wittchen HU, Jönsson B, Olesen J, Group CS (2010) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21(10):718–779CrossRef
3.
go back to reference Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, Benabid AL (1998) Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 339(16):1105–1111CrossRefPubMed Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, Benabid AL (1998) Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 339(16):1105–1111CrossRefPubMed
4.
go back to reference Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C et al (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349(20):1925–1934CrossRefPubMed Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C et al (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349(20):1925–1934CrossRefPubMed
5.
go back to reference Schuepbach W, Rau J, Knudsen K, Volkmann J, Krack P, Timmermann L, Halbig T et al (2013) Neurostimulation for Parkinson’s disease with early motor complications. N Engl J Med 368:610–622CrossRefPubMed Schuepbach W, Rau J, Knudsen K, Volkmann J, Krack P, Timmermann L, Halbig T et al (2013) Neurostimulation for Parkinson’s disease with early motor complications. N Engl J Med 368:610–622CrossRefPubMed
6.
go back to reference Weaver F, Follett K, Stern M, Hur K, Harris C, Marks Jnr W et al (2009) Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson’s disease. JAMA 301(1):63–73CrossRefPubMedPubMedCentral Weaver F, Follett K, Stern M, Hur K, Harris C, Marks Jnr W et al (2009) Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson’s disease. JAMA 301(1):63–73CrossRefPubMedPubMedCentral
7.
go back to reference Fasano A, Daniele A, Albanese A (2012) Treatment of motor and non-motor features of Parkinson’s disease with deep brain stimulation. Lancet Neurol 11(5):429–442CrossRefPubMed Fasano A, Daniele A, Albanese A (2012) Treatment of motor and non-motor features of Parkinson’s disease with deep brain stimulation. Lancet Neurol 11(5):429–442CrossRefPubMed
8.
go back to reference Odekerken V, van Laar T, Staal M, Mosch A, Hoffmann C, Nijssen P, Beute GN et al (2013) Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial. Lancet Neurol 12(1):37–44CrossRefPubMed Odekerken V, van Laar T, Staal M, Mosch A, Hoffmann C, Nijssen P, Beute GN et al (2013) Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial. Lancet Neurol 12(1):37–44CrossRefPubMed
9.
go back to reference Perestelo-Pérez L, Rivero-Santana A, Pérez-Ramos J, Serrano-Pérez P, Panetta J, Hilarion P (2014) Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials. J Neurol 261(11):2051–2060CrossRefPubMed Perestelo-Pérez L, Rivero-Santana A, Pérez-Ramos J, Serrano-Pérez P, Panetta J, Hilarion P (2014) Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials. J Neurol 261(11):2051–2060CrossRefPubMed
10.
go back to reference Xie CL, Shao B, Chen J, Zhou Y, Lin SY, Wang WW (2016) Effects of neurostimulation for advanced Parkinson’s disease patients on motor symptoms: a multiple-treatments meta-analysas of randomized controlled trials. Sci Rep 6:25285CrossRefPubMedPubMedCentral Xie CL, Shao B, Chen J, Zhou Y, Lin SY, Wang WW (2016) Effects of neurostimulation for advanced Parkinson’s disease patients on motor symptoms: a multiple-treatments meta-analysas of randomized controlled trials. Sci Rep 6:25285CrossRefPubMedPubMedCentral
11.
go back to reference Fraix V, Houeto JL, Lagrange C, Le Pen C, Krystkowiak P, Guehl D, Ardouin C, Welter ML, Maurel F, Defebvre L, Rougier A, Benabid AL, Mesnage V, Ligier M, Blond S, Burbaud P, Bioulac B, Destée A, Cornu P, Pollak P, SPARK Study Group (2006) Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson’s disease. J Neurol Neurosurg Psychiatry 77(4):443–449CrossRefPubMedPubMedCentral Fraix V, Houeto JL, Lagrange C, Le Pen C, Krystkowiak P, Guehl D, Ardouin C, Welter ML, Maurel F, Defebvre L, Rougier A, Benabid AL, Mesnage V, Ligier M, Blond S, Burbaud P, Bioulac B, Destée A, Cornu P, Pollak P, SPARK Study Group (2006) Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson’s disease. J Neurol Neurosurg Psychiatry 77(4):443–449CrossRefPubMedPubMedCentral
12.
go back to reference Valldeoriola F, Morsi O, Tolosa E, Rumia J, Marti M, Martínez-Martín P (2007) Prospective comparative study on cost-effectiveness of subthalamic stimulation and best medical treatment in advanced Parkinson’s disease. Mov Disord 22(15):2183–2191CrossRefPubMed Valldeoriola F, Morsi O, Tolosa E, Rumia J, Marti M, Martínez-Martín P (2007) Prospective comparative study on cost-effectiveness of subthalamic stimulation and best medical treatment in advanced Parkinson’s disease. Mov Disord 22(15):2183–2191CrossRefPubMed
13.
go back to reference Dams J, Dodel R (2016) An economic evaluation of deep brain stimulation for patients with Parkinson’s disease. Mov Disord 31(8):1122–1124CrossRefPubMed Dams J, Dodel R (2016) An economic evaluation of deep brain stimulation for patients with Parkinson’s disease. Mov Disord 31(8):1122–1124CrossRefPubMed
14.
go back to reference Dams J, Balzer-Geldsetzer M, Siebert U, Deuschl G, Schuepbach WM, Krack P, Timmermann L, Schnitzler A, Reese JP, Dodel R, EARLYSTIM-investigators (2016) Cost-effectiveness of neurostimulation in Parkinson’s disease with early motor complications. Mov Disord 31(8):1183–1191CrossRefPubMed Dams J, Balzer-Geldsetzer M, Siebert U, Deuschl G, Schuepbach WM, Krack P, Timmermann L, Schnitzler A, Reese JP, Dodel R, EARLYSTIM-investigators (2016) Cost-effectiveness of neurostimulation in Parkinson’s disease with early motor complications. Mov Disord 31(8):1183–1191CrossRefPubMed
15.
go back to reference Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR (2011) Deep brain stimulation for Parkinson disease. An expert consensus and review of key issues. Arch Neurol 68(2):165–171CrossRefPubMed Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR (2011) Deep brain stimulation for Parkinson disease. An expert consensus and review of key issues. Arch Neurol 68(2):165–171CrossRefPubMed
17.
go back to reference Martens L, Goode G, Wold JF, Beck L, Martin G, Perings C, Stolt P, Baggerman L (2014) Structured syncope care pathways based on lean six sigma methodology optimises resource use with shorter time to diagnosis and increased diagnostic yield. PLoS One 9(6):e100208CrossRefPubMedPubMedCentral Martens L, Goode G, Wold JF, Beck L, Martin G, Perings C, Stolt P, Baggerman L (2014) Structured syncope care pathways based on lean six sigma methodology optimises resource use with shorter time to diagnosis and increased diagnostic yield. PLoS One 9(6):e100208CrossRefPubMedPubMedCentral
18.
go back to reference Thobois S, Mertens P, Guenot M, Hermier M, Mollion H, Bouvard M, Chazot G, Broussolle E, Sindou M (2002) Subthalamic nucleus stimulation in Parkinson’s disease: clinical evaluation of 18 patients. J Neurol 249(5):529–534CrossRefPubMed Thobois S, Mertens P, Guenot M, Hermier M, Mollion H, Bouvard M, Chazot G, Broussolle E, Sindou M (2002) Subthalamic nucleus stimulation in Parkinson’s disease: clinical evaluation of 18 patients. J Neurol 249(5):529–534CrossRefPubMed
19.
go back to reference Gervais-Bernard H, Xie-Brustolin J, Mertens P, Polo G, Klinger H, Adamec D, Broussolle E, Thobois S (2009) Bilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: five year follow-up. J Neurol 256(2):225–233CrossRefPubMed Gervais-Bernard H, Xie-Brustolin J, Mertens P, Polo G, Klinger H, Adamec D, Broussolle E, Thobois S (2009) Bilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: five year follow-up. J Neurol 256(2):225–233CrossRefPubMed
20.
go back to reference Volkmann J, Albanese A, Antonini A, Chaudhuri K, Clarke C, de Bie R, Deuschl G, Eggert K et al (2013) Selecting deep brain stimulation or infusion therapies in advanced Parkinson’s disease: an evidence-based review. J Neurol 260(11):2701–2714CrossRefPubMedPubMedCentral Volkmann J, Albanese A, Antonini A, Chaudhuri K, Clarke C, de Bie R, Deuschl G, Eggert K et al (2013) Selecting deep brain stimulation or infusion therapies in advanced Parkinson’s disease: an evidence-based review. J Neurol 260(11):2701–2714CrossRefPubMedPubMedCentral
23.
go back to reference Nagendran ST, Siah WF, Litwin A, Barbosa C, Jayatilake J, Malhotra R (2016) How can we maximize the use of our operating lists? An analysis of factors influencing theatre efficiency in oculoplastic day surgery. Orbit. doi:10.1080/01676830.2016.1193534 Nagendran ST, Siah WF, Litwin A, Barbosa C, Jayatilake J, Malhotra R (2016) How can we maximize the use of our operating lists? An analysis of factors influencing theatre efficiency in oculoplastic day surgery. Orbit. doi:10.​1080/​01676830.​2016.​1193534
24.
go back to reference Chamberlain M, Pugh H (2015) Improving inpatient care with the introduction of a hip fracture pathway. BMJ Qual Improv Rep 4(1) ([pii]: u204075.w202786) Chamberlain M, Pugh H (2015) Improving inpatient care with the introduction of a hip fracture pathway. BMJ Qual Improv Rep 4(1) ([pii]: u204075.w202786)
25.
go back to reference Davey V, Harris G, Dijkstra B, James M, Robinson B (2014) A review of the Christchurch Hospital Breast Cancer Service in 2012: meeting the new Tumour Standards. N Z Med J 127(1399):58–73PubMed Davey V, Harris G, Dijkstra B, James M, Robinson B (2014) A review of the Christchurch Hospital Breast Cancer Service in 2012: meeting the new Tumour Standards. N Z Med J 127(1399):58–73PubMed
26.
go back to reference Young C, Abercrombie M, Beattie A (2003) How a specialist nurse helps patients undergoing deep brain stimulation. Prof Nurse 18(6):318–321PubMed Young C, Abercrombie M, Beattie A (2003) How a specialist nurse helps patients undergoing deep brain stimulation. Prof Nurse 18(6):318–321PubMed
27.
go back to reference Katz M, Kilbane C, Rosengard J, Alterman RL, Tagliati M (2011) Referring patients for deep brain stimulation: an improving practice. Arch Neurol 68(8):1027–1032CrossRefPubMed Katz M, Kilbane C, Rosengard J, Alterman RL, Tagliati M (2011) Referring patients for deep brain stimulation: an improving practice. Arch Neurol 68(8):1027–1032CrossRefPubMed
28.
go back to reference Moro E, Schüpbach M, Wächter T, Allert N, Eleopra R, Honey CR, Rueda M, Schiess MC, Shimo Y, Valkovic P, Whone A, Stoevelaar H (2016) Referring Parkinson’s disease patients for deep brain stimulation: a RAND/UCLA appropriateness study. J Neurol 263(1):112–119CrossRefPubMed Moro E, Schüpbach M, Wächter T, Allert N, Eleopra R, Honey CR, Rueda M, Schiess MC, Shimo Y, Valkovic P, Whone A, Stoevelaar H (2016) Referring Parkinson’s disease patients for deep brain stimulation: a RAND/UCLA appropriateness study. J Neurol 263(1):112–119CrossRefPubMed
29.
go back to reference Oyama G, Rodriguez RL, Jones JD, Swartz C, Merritt S, Unger R, Hubmann M, Delgado A, Simon E, Doniger GM, Bowers D, Foote KD, Fernandez HH, Okun MS (2012) Selection of deep brain stimulation candidates in private neurology practices: referral may be simpler than a computerized triage system. Neuromodulation 15(3):246–250CrossRefPubMed Oyama G, Rodriguez RL, Jones JD, Swartz C, Merritt S, Unger R, Hubmann M, Delgado A, Simon E, Doniger GM, Bowers D, Foote KD, Fernandez HH, Okun MS (2012) Selection of deep brain stimulation candidates in private neurology practices: referral may be simpler than a computerized triage system. Neuromodulation 15(3):246–250CrossRefPubMed
31.
go back to reference Jones B, Hopkins G, Wherry SA, Lueck CJ, Das CP, Dugdale P (2016) Evaluation of a regional Australian nurse-led Parkinson’s service using the context, input, process, and product evaluation model. Clin Nurse Spec 30(5):264–270CrossRefPubMed Jones B, Hopkins G, Wherry SA, Lueck CJ, Das CP, Dugdale P (2016) Evaluation of a regional Australian nurse-led Parkinson’s service using the context, input, process, and product evaluation model. Clin Nurse Spec 30(5):264–270CrossRefPubMed
32.
go back to reference Surendranath S (2014) Parkinson’s nurses: a light in the darkness. Nurs Older People 26(9):16–20CrossRefPubMed Surendranath S (2014) Parkinson’s nurses: a light in the darkness. Nurs Older People 26(9):16–20CrossRefPubMed
33.
go back to reference Hellqvist C, Berterö C (2015) Support supplied by Parkinson’s disease specialist nurses to Parkinson’s disease patients and their spouses. Appl Nurs Res 28(2):86–91CrossRefPubMed Hellqvist C, Berterö C (2015) Support supplied by Parkinson’s disease specialist nurses to Parkinson’s disease patients and their spouses. Appl Nurs Res 28(2):86–91CrossRefPubMed
34.
go back to reference Lanier-Bohan EM, Heath SL (2016) Patient and caregiver perspectives of preoperative teaching for deep brain stimulation surgery. J Neurosci Nurs 48(5):247–255CrossRefPubMed Lanier-Bohan EM, Heath SL (2016) Patient and caregiver perspectives of preoperative teaching for deep brain stimulation surgery. J Neurosci Nurs 48(5):247–255CrossRefPubMed
35.
go back to reference Alesch F, Jain R, Chen L, Brucke T, Seijo F, San Martin ES, Haegelen C, Verin M, Maarouf M, Barbe MT, Gill S, Whone A, Porta M, Servello D, Timmermann L (2016) 135A omparison of outcomes between deep brain stimulation under general anesthesia versus conscious sedation with awake evaluation. Neurosurgy 63(Suppl 1):155CrossRef Alesch F, Jain R, Chen L, Brucke T, Seijo F, San Martin ES, Haegelen C, Verin M, Maarouf M, Barbe MT, Gill S, Whone A, Porta M, Servello D, Timmermann L (2016) 135A omparison of outcomes between deep brain stimulation under general anesthesia versus conscious sedation with awake evaluation. Neurosurgy 63(Suppl 1):155CrossRef
36.
go back to reference Saleh S, Swanson KI, Lake WB, Sillay KA (2015) Awake neurophysiologically guided versus asleep MRI-guided STN DBS for Parkinson Disease: a comparison of outcomes using levodopa equivalents. Stereotact Funct Neurosurg 93(6):419–426CrossRefPubMed Saleh S, Swanson KI, Lake WB, Sillay KA (2015) Awake neurophysiologically guided versus asleep MRI-guided STN DBS for Parkinson Disease: a comparison of outcomes using levodopa equivalents. Stereotact Funct Neurosurg 93(6):419–426CrossRefPubMed
37.
go back to reference Hyam JA, Akram H, Foltynie T, Limousin P, Hariz M, Zrinzo L (2015) What you see is what you get: lead location within deep brain structures is accurately depicted by stereotactic magnetic resonance imaging. Neurosurgery 11(Suppl 3):412–419CrossRefPubMed Hyam JA, Akram H, Foltynie T, Limousin P, Hariz M, Zrinzo L (2015) What you see is what you get: lead location within deep brain structures is accurately depicted by stereotactic magnetic resonance imaging. Neurosurgery 11(Suppl 3):412–419CrossRefPubMed
38.
go back to reference Southwell DG, Narvid JA, Martin AJ, Qasim SE, Starr PA, Larson PS (2016) Comparison of deep brain stimulation lead targeting accuracy and procedure duration between 1.5- and 3-Tesla interventional magnetic resonance imaging systems: an initial 12-month experience. Stereotact Funct Neurosurg 94(2):102–107CrossRefPubMed Southwell DG, Narvid JA, Martin AJ, Qasim SE, Starr PA, Larson PS (2016) Comparison of deep brain stimulation lead targeting accuracy and procedure duration between 1.5- and 3-Tesla interventional magnetic resonance imaging systems: an initial 12-month experience. Stereotact Funct Neurosurg 94(2):102–107CrossRefPubMed
39.
go back to reference Bour LJ, Contarino MF, Foncke EM, de Bie RM, van den Munckhof P, Speelman JD, Schuurman PR (2010) Long-term experience with intraoperative microrecording during DBS neurosurgery in STN and GPi. Acta Neurochir (Wien) 152(12):2069–2077CrossRef Bour LJ, Contarino MF, Foncke EM, de Bie RM, van den Munckhof P, Speelman JD, Schuurman PR (2010) Long-term experience with intraoperative microrecording during DBS neurosurgery in STN and GPi. Acta Neurochir (Wien) 152(12):2069–2077CrossRef
Metadata
Title
Optimizing the deep brain stimulation care pathway in patients with Parkinson’s disease
Authors
N. J. Thomas
P. Mertens
T. Danaila
G. Polo
H. Klinger
E. Broussolle
S. Thobois
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 7/2017
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-017-8548-2

Other articles of this Issue 7/2017

Journal of Neurology 7/2017 Go to the issue

Pioneers in Neurology

Jacob Heine (1800–1879)