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Published in: Journal of Neurology 5/2015

01-05-2015 | Original Communication

The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study

Authors: Domenico Consoli, Simone Vidale, Umberto Aguglia, Pietro Bassi, Anna Cavallini, Arturo Consoli, Franco Galati, Donata Guidetti, Giuseppe Micieli, Giuseppe Neri, Maurizia Rasura, Roberto Sterzi, Danilo Toni, Domenico Inzitari

Published in: Journal of Neurology | Issue 5/2015

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Abstract

Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56 %) patients were enrolled in this prospective case–control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1 %) and 207 (23.6 %) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95 % CI 1.02–1.09; p < 0.001) and PSIs and IgA antichlamydia pneumoniae seropositivity (RR: 3.84; 95 % CI 2.53–5.84; p < 0.001). Significant disability was associated with baseline NIHSS (RR: 1.32; 95 % CI 1.16–1.50; p < 0.001), IgA (RR: 2.67; 95 % CI 1.06–6.70; p = 0.035) and IgG antichlamydia (RR: 5.75; 95 % CI 1.83–18.03; p = 0.003) seropositivity and atrial fibrillation (RR: 2.58; 95 % CI 1.81–3.67; p < 0.001). While previous infections were not associated with functional outcome, antichlamydia antibodies play a negative role in ischemic stroke patients. Preventive strategies may reduce the stroke burden and improve the clinical outcome.
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Metadata
Title
The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study
Authors
Domenico Consoli
Simone Vidale
Umberto Aguglia
Pietro Bassi
Anna Cavallini
Arturo Consoli
Franco Galati
Donata Guidetti
Giuseppe Micieli
Giuseppe Neri
Maurizia Rasura
Roberto Sterzi
Danilo Toni
Domenico Inzitari
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 5/2015
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-015-7712-9

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