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01-08-2015 | Review

Neurogenic muscle cramps

Author: Hans D. Katzberg

Published in: Journal of Neurology | Issue 8/2015

Abstract

Muscle cramps are sustained, painful contractions of muscle and are prevalent in patients with and without medical conditions. The objective of this review is to present updates on the mechanism, investigation and treatment of neurogenic muscle cramps. PubMed and Embase databases were queried between January 1980 and July 2014 for English-language human studies. The American Academy of Neurology classification of studies (classes I–IV) was used to assess levels of evidence. Mechanical disruption, ephaptic transmission, disruption of sensory afferents and persistent inward currents have been implicated in the pathogenesis of neurogenic cramps. Investigations are directed toward identifying physiological triggers or medical conditions predisposing to cramps. Although cramps can be self-limiting, disabling or sustained muscle cramps should prompt investigation for underlying medical conditions. Lifestyle modifications, treatment of underlying conditions, stretching, B-complex vitamins, diltiezam, mexiletine, carbamazepine, tetrahydrocannabinoid, leveteracitam and quinine sulfate have shown evidence for treatment.

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Title: Neurogenic muscle cramps
Author: Hans D. Katzberg
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 8/2015
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-015-7659-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Neurogenic muscle cramps

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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