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Journal of Neurology
Published in: Journal of Neurology 10/2014

01-10-2014 | Original Communication

Cerebellar metabolic involvement and its correlations with clinical parameters in vestibular neuritis

Authors: Marco Alessandrini, Alessandro Micarelli, Agostino Chiaravalloti, Matteo Candidi, Ernesto Bruno, Barbara Di Pietro, Johanna Öberg, Orazio Schillaci, Marco Pagani

Published in: Journal of Neurology | Issue 10/2014

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Abstract

Although vestibular neuritis (VN) cortical models are described in the literature, there is lack of knowledge regarding the exclusive cerebellar involvement. The aim of the present study was to analyze, by [18F] fluorodeoxyglucose-positron emission tomography (FDG-PET)/computer tomography, regional cerebellar FDG uptake in eight right-handed VN patients (five females; three males; mean age 48 ± 7 years) during the first few days (PET0) and after 1 month (PET1) since symptoms onset. At both phases, patients underwent otoneurological examination and filled in a battery of validated questionnaires. Twenty-six cerebellar volumes of interest (VOI) were identified by the automated anatomical labeling library and normalized to thalamus FDG-PET uptake. Mean intensity within VOIs was calculated in both phases and processed by within-subjects ANOVA. A significantly lower (p < 0.005) FDG uptake distribution was found in bilateral lobules III, VI and X and in vermis 1–2, 3, 6 and 10 at PET0 as compared to PET1 and a significant higher FDG uptake distribution was found in right crus I in the same comparison. Significant (p < 0.05) positive correlations were found between Anxiety and Bucket test scores, and normalized metabolism in right crus I (at PET0) and vermis 10 (at PET1), respectively. A negative correlation was found at PET0 between slow-phase velocity scores and normalized metabolism in right lobule X. These data show relevant changes in the pattern of cerebellar metabolism that might unravel additional central aspects of early and late VN associated to bilateral cortical responses to sensory conflict during the acute VN-related controversial inflow.
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Metadata
Title
Cerebellar metabolic involvement and its correlations with clinical parameters in vestibular neuritis
Authors
Marco Alessandrini
Alessandro Micarelli
Agostino Chiaravalloti
Matteo Candidi
Ernesto Bruno
Barbara Di Pietro
Johanna Öberg
Orazio Schillaci
Marco Pagani
Publication date
01-10-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 10/2014
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-014-7449-x

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