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01-01-2010 | Original Communication

Antineuronal antibodies in sporadic late-onset cerebellar ataxia

Authors: K. Bürk, M. Wick, G. Roth, P. Decker, R. Voltz

Published in: Journal of Neurology | Issue 1/2010

Abstract

Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the patients. The present findings suggest an autoimmune contribution to the pathophysiology of a subgroup of sporadic late-onset cerebellar ataxia.

Harding AE (1981) “Idiopathic” late onset cerebellar ataxia. A clinical and genetic study of 36 cases. J Neurol Sci 51(2):259–271CrossRefPubMed

Dalmau JO, Rosenfeld MR (2009) Paraneoplastic syndromes of the CNS. Lancet Neurol 7(4):327–340CrossRef

Voltz R, Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB et al (1999) A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. N Engl J Med 340(23):1788–1795CrossRefPubMed

Lennon VA, Kryzer TJ, Griesmann GE, O’Suilleabhain PE, Windebank AJ, Woppmann A et al (1995) Calcium-channel antibodies in the Lambert–Eaton syndrome and other paraneoplastic syndromes. N Engl J Med 332(22):1467–1474CrossRefPubMed

Motomura M, Johnston I, Lang B, Vincent A, Newsom-Davis J (1995) An improved diagnostic assay for Lambert–Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatry 58(1):85–87CrossRefPubMed

Gilman S, Low PA, Quinn N, Albanese A, Ben Shlomo Y, Fowler CJ et al (1999) Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 163(1):94–98CrossRefPubMed

Burk K, Melms A, Schulz JB, Dichgans J (2001) Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 50(6):827–828CrossRefPubMed

Hadjivassiliou M, Grunewald RA, Chattopadhyay AK, Davies-Jones GA, Gibson A, Jarratt JA et al (1998) Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia. Lancet 352(9140):1582–1585CrossRefPubMed

Candler PM, Hart PE, Barnett M, Weil R, Rees JH (2004) A follow up study of patients with paraneoplastic neurological disease in the UK. J Neurol Neurosurg Psychiatry 75(10):1411–1415CrossRefPubMed

10.

Wullner U, Klockgether T, Petersen D, Naegele T, Dichgans J (1993) Magnetic resonance imaging in hereditary and idiopathic ataxia. Neurology 43(2):318–325PubMed

11.

Darnell RB, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349(16):1543–1554CrossRefPubMed

Title: Antineuronal antibodies in sporadic late-onset cerebellar ataxia
Authors: K. Bürk
M. Wick
G. Roth
P. Decker
R. Voltz
Publication date: 01-01-2010
Publisher: D. Steinkopff-Verlag
Published in: Journal of Neurology / Issue 1/2010
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-009-5262-8

At a glance: The STEP trials

Springer Medicine

Antineuronal antibodies in sporadic late-onset cerebellar ataxia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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