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01-01-2010 | Letter to the Editors

Oculomotor disorders in adult-onset Still’s disease

Authors: Aasef G. Shaikh, Timothy C. Hain, David S. Zee

Published in: Journal of Neurology | Issue 1/2010

Excerpt

A patient with adult-onset Still’s disease (AOSD)¹ developed periodic horizontal micro-saccadic oscillations and periodic rapid clockwise torsional eye movements followed by counterclockwise torsional drifts (see video). Neuroimaging studies were normal. Tests for paraneoplastic antibodies were negative. Details of the clinical presentation and experimental methods are presented in supplementary material 1. …

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AOSD is an idiopathic arthritis with spiking fevers and transient maculopapular rash.

Das VE, Oruganti P, Kramer PD, Leigh RJ (2000) Experimental tests of a neural-network model for ocular oscillations caused by disease of central myelin. Exp Brain Res 133:189–197CrossRefPubMed

Enderle JD, Engelken EJ (1995) Simulation of oculomotor post-inhibitory rebound burst firing using a Hodgkin–Huxley model of a neuron. Biomed Sci Instrum 31:53–58PubMed

Miura K, Optican LM (2006) Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons. J Comput Neurosci 20:25–41CrossRefPubMed

Perez-Reyes E (2003) Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 83:117–161PubMed

Ramat S, Leigh RJ, Zee DS, Optican LM (2005) Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons. Exp Brain Res 160:89–106CrossRefPubMed

Ramat S, Leigh RJ, Zee DS, Optican LM (2007) What clinical disorders tell us about the neural control of saccadic eye movements. Brain 130:10–35CrossRefPubMed

Shaikh AG, Miura K, Optican LM, Ramat S, Leigh RJ, Zee DS (2007) A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders. Brain 130:3020–3031CrossRefPubMed

Shaikh AG, Ramat S, Optican LM, Miura K, Leigh RJ, Zee DS (2008) Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations. J Neuroophthalmol 28:329–336PubMed

Zerrate MD, Shaikh A, Zee D, Troncoso J, Pardo CA (2006) Ion channel profile of human brainstem saccadic burst neurons. Program: 345.3, 2006; Neuroscience Meeting Planner. Altlanta, GA: Society for Neuroscience, Online

Title: Oculomotor disorders in adult-onset Still’s disease
Authors: Aasef G. Shaikh
Timothy C. Hain
David S. Zee
Publication date: 01-01-2010
Publisher: D. Steinkopff-Verlag
Published in: Journal of Neurology / Issue 1/2010
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-009-5308-y

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Oculomotor disorders in adult-onset Still’s disease

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