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Open Access 01-07-2017 | Original Article

Increasing the reference populations for the 55 AISNP panel: the need and benefits

Authors: Andrew J. Pakstis, Longli Kang, Lijun Liu, Zhiying Zhang, Tianbo Jin, Elena L. Grigorenko, Frank R. Wendt, Bruce Budowle, Sibte Hadi, Mariam Salam Al Qahtani, Niels Morling, Helle Smidt Mogensen, Goncalo E. Themudo, Usha Soundararajan, Haseena Rajeevan, Judith R. Kidd, Kenneth K. Kidd

Published in: International Journal of Legal Medicine | Issue 4/2017

Abstract

Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have data available for the SNPs studied, then analyses based on DNA evidence may indicate a quite distantly related population, albeit one among the more closely related of the existing reference populations. We have added reference population allele frequencies for 14 additional population samples (with >1100 individuals studied) to the 125 population samples previously published for the Kidd Lab 55 AISNP panel. Allele frequencies are now publicly available for all 55 SNPs in ALFRED and FROG-kb for a total of 139 population samples. This Kidd Lab panel of 55 ancestry informative SNPs has been incorporated in commercial kits by both ThermoFisher Scientific and Illumina for massively parallel sequencing. Researchers employing those kits will find the enhanced set of reference populations useful.

Available only for authorised users

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Title: Increasing the reference populations for the 55 AISNP panel: the need and benefits
Authors: Andrew J. Pakstis
Longli Kang
Lijun Liu
Zhiying Zhang
Tianbo Jin
Elena L. Grigorenko
Frank R. Wendt
Bruce Budowle
Sibte Hadi
Mariam Salam Al Qahtani
Niels Morling
Helle Smidt Mogensen
Goncalo E. Themudo
Usha Soundararajan
Haseena Rajeevan
Judith R. Kidd
Kenneth K. Kidd
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 4/2017
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-016-1524-z

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Increasing the reference populations for the 55 AISNP panel: the need and benefits

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