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01-09-2016 | Letter to the Editor

Mutations of short tandem repeat loci in cases of paternity testing in Chinese

Authors: Mao Sun, XiaoNan Zhang, Dan Wu, Qi Shen, YuanMing Wu, ShanMin Fu

Published in: International Journal of Legal Medicine | Issue 5/2016

Abstract

In order to find out the characteristics of genetic mutations in 15 short tandem repeat (STR) loci, 3734 parentage cases were analyzed using AmpFlSTR Sinofiler kit. The allele source, mutation rate, and mutation rule of the STR loci were determined. Seventy mutations were observed in all cases for paternity testing. Among 15 STR loci, the highest mutation rate was observed in D12S391 (0.21 %), but the D5S818 gene mutation rate was relatively low (0.02 %). One-step mutation cases accounted for 95.7 % of all of the cases monitored. And the mutations in this study mainly showed paternal mutation (64/70). The research results are of great significance for identification and paternity tests and for the improvement of genetic studies on Chinese population in the future.

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Title: Mutations of short tandem repeat loci in cases of paternity testing in Chinese
Authors: Mao Sun
XiaoNan Zhang
Dan Wu
Qi Shen
YuanMing Wu
ShanMin Fu
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 5/2016
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-015-1229-8

ACC 2024 Congress

Springer Medicine

Mutations of short tandem repeat loci in cases of paternity testing in Chinese

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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