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Open Access 01-02-2020 | Sleep Apnea | SLEEP

Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients

Authors: P. Horváth, Z. Lázár, G. Gálffy, R. Puskás, L. Kunos, Gy. Losonczy, M. Mészáros, Á. D. Tárnoki, D. L. Tárnoki, A. Bikov

Published in: Lung | Issue 1/2020

Abstract

Purpose

Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.

Methods

Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h.

Results

PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8, p = 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml, p = 0.006) and controls (p = 0.03).

Conclusions

P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.

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Title: Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients
Authors: P. Horváth
Z. Lázár
G. Gálffy
R. Puskás
L. Kunos
Gy. Losonczy
M. Mészáros
Á. D. Tárnoki
D. L. Tárnoki
A. Bikov
Publication date: 01-02-2020
Publisher: Springer US
Keywords: Sleep Apnea
Polysomnography
Published in: Lung / Issue 1/2020
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-019-00299-0

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