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Open Access 01-08-2019 | SLEEP

Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep

Authors: Andras Bikov, Zsofia Lazar, Peter Horvath, David Laszlo Tarnoki, Adam Domonkos Tarnoki, Luca Fesus, Marton Horvath, Martina Meszaros, Gyorgy Losonczy, Laszlo Kunos

Published in: Lung | Issue 4/2019

Abstract

Purpose

Obstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. Obstructive respiratory events during rapid eye movement (REM) sleep are more strongly related to the development of hypertension and diabetes than in non-REM. However, the relationship between sleep phases and serum lipid profile is unclear. We aimed to analyse the relationship between obstructive respiratory events in REM and non-REM sleep as well as serum lipid profile.

Methods

Polysomnography was performed in 94 adult subjects who did not take any lipid-modifying medications. Fasting venous blood sample was taken the following morning for total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, lipoprotein(a), apoprotein A1 (ApoA1) and for apoprotein B (ApoB) measurements. Lipid profiles were correlated with apnoea–hypopnoea index (AHI) during REM (AHI_REM) and non-REM (AHI_NREM) stages in all subjects. In addition, lipid profiles were compared between REM-dependent OSA patients (AHI_REM ≥ 5/h, but AHI_NREM < 5/h) and control subjects (both AHI_REM and AHI_NREM < 5/h).

Results

AHI_REM correlated only with triglyceride concentrations (p = 0.04, Spearman’s rho, ρ = 0.21). In contrast, there was a significant association between AHI_NREM and triglyceride (p = 0.02, ρ = 0.23), ApoB (p = 0.03, ρ = 0.21), HDL-C (p < 0.01, ρ = − 0.32) as well as ApoA1 levels (p = 0.04, ρ = − 0.21). However, these correlations were not present after adjustment for BMI (all p > 0.05). There was no difference in the lipid profile of REM-dependent OSA subjects and healthy controls (p > 0.05).

Conclusions

Altered serum lipid profile is equally associated with a disturbed REM and non-REM sleep in OSA. Obesity must be considered as a strong covariate when interpreting lipid data in sleep apnoea.

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Title: Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep
Authors: Andras Bikov
Zsofia Lazar
Peter Horvath
David Laszlo Tarnoki
Adam Domonkos Tarnoki
Luca Fesus
Marton Horvath
Martina Meszaros
Gyorgy Losonczy
Laszlo Kunos
Publication date: 01-08-2019
Publisher: Springer US
Published in: Lung / Issue 4/2019
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-019-00195-7

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