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Lung
Published in: Lung 1/2019

01-02-2019 | LUNG IMAGES

Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation

Authors: Tiara Boghanim, Marlène Murris, Tatiana Lamon, Anne Huynh, Julien Mazières, Charles-Hugo Marquette, Alain Didier

Published in: Lung | Issue 1/2019

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Abstract

We report a case of thoracic air-leak syndrome, an extremely rare complication developed after an episode of organizing pneumonia due to graft-vs-host disease in a 19-year-old male. This unusual non-infectious pulmonary complication occurred 527 days after allogeneic HSCT and led to the patient’s death within 1 month due to cardio-respiratory failure. Herein, we highlight chest-imaging aspects which are typical. Early detection by high-resolution chest CT could improve patient management.
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Moon MH, Sa YJ, Cho KD, Jo KH, Lee SH, Sim SB (2010) Thoracic air-leak syndromes in hematopoietic stem cell transplant recipients with graft-versus-host disease: a possible sign for poor response to treatment and poor prognosis. J Korean Med Sci 25(5):658–662CrossRefPubMedPubMedCentral
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Vogel M, Brodoefel H, Bethge W, Faul C, Hartmann J, Schimmel H et al (2006) Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: causes, CT-follow up and patient outcome. Eur J Radiol 60(3):392–397CrossRefPubMed
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Toubai T, Tanaka J, Kobayashi N, Honda T, Miura Y, Ogawa T et al (2004) Mediastinal emphysema and bilateral pneumothoraces with chronic GVHD in patients after allogeneic stem cell transplantation. Bone Marrow Transplant 33(11):1159–1163CrossRefPubMed
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Sakai R, Kanamori H, Nakaseko C, Yoshiba F, Fujimaki K, Sakura T et al (2011) Air-leak syndrome following allo-SCT in adult patients: report from the Kanto Study Group for Cell Therapy in Japan. Bone Marrow Transplant 46(3):379–384CrossRefPubMed
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Metadata
Title
Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation
Authors
Tiara Boghanim
Marlène Murris
Tatiana Lamon
Anne Huynh
Julien Mazières
Charles-Hugo Marquette
Alain Didier
Publication date
01-02-2019
Publisher
Springer US
Published in
Lung / Issue 1/2019
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-018-0173-z

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