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01-02-2017

A Paradox: α-Klotho Levels and Smoking Intensity

Authors: Zoraida Verde, Jose M. Rodríguez González-Moro, Luis M. Chicharro, Luis Reinoso-Barbero, Fernando Bandrés, Félix Gómez-Gallego, Catalina Santiago

Published in: Lung | Issue 1/2017

Abstract

Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.

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Title: A Paradox: α-Klotho Levels and Smoking Intensity
Authors: Zoraida Verde
Jose M. Rodríguez González-Moro
Luis M. Chicharro
Luis Reinoso-Barbero
Fernando Bandrés
Félix Gómez-Gallego
Catalina Santiago
Publication date: 01-02-2017
Publisher: Springer US
Published in: Lung / Issue 1/2017
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-016-9944-6

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