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Lung
Published in: Lung 2/2011

01-04-2011

Aspergillus Lung Disease in Patients with Sarcoidosis: A Case Series and Review of the Literature

Authors: Tahuanty A. Pena, Ayman O. Soubani, Lobelia Samavati

Published in: Lung | Issue 2/2011

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Abstract

Chronic cavitary pulmonary aspergillosis (CCPA) has been associated with advanced lung diseases. Pulmonary sarcoidosis, a granulomatous inflammatory disorder, is associated with CCPA. We identified CCPA in 2% of cases in a large cohort of sarcoidosis patients. We found a lack of response to medical treatment and poor outcome in this subgroup.
Literature
1.
Walsh TJ, Anaissie EJ, Denning DW et al (2008) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46(3):327–360PubMedCrossRef
2.
Denning DW, Riniotis K, Dobrashian R et al (2003) Chronic cavitary and fibrosing pulmonary and pleural aspergillosis: case series, proposed nomenclature change, and review. Clin Infect Dis 37(Suppl 3):S265–S280PubMedCrossRef
3.
Wollschlager C, Khan F (1984) Aspergillomas complicating sarcoidosis. A prospective study in 100 patients. Chest 86(4):585–588PubMedCrossRef
4.
[No authors listed] (1999) Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 160(2):736–755
5.
Marzouk K, Saleh S, Kannass M et al (2004) Interferon-induced granulomatous lung disease. Curr Opin Pulm Med 10(5):435–440PubMedCrossRef
6.
Girard N, Cottin V, Hot A et al (2004) Opportunistic infections and sarcoidosis. Rev Mal Respir 21(6 Pt 1):1083–1090PubMed
7.
Baughman RP, Lower EE (2005) Fungal infections as a complication of therapy for sarcoidosis. QJM 98(6):451–456PubMedCrossRef
8.
Lachkar S, Dominique S, Thiberville L et al (2007) Aspergillosis and sarcoidosis. Rev Mal Respir 24(8):943–953PubMed
9.
De Pauw B, Walsh TJ, Donnelly JP et al (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 46(12):1813–1821PubMedCrossRef
10.
Samarakoon P, Soubani AO (2008) Invasive pulmonary aspergillosis in patients with COPD: a report of five cases and systematic review of the literature. Chron Respir Dis 5(1):19–27PubMedCrossRef
11.
Muller NL, Kullnig P, Miller RR (1989) The CT findings of pulmonary sarcoidosis: analysis of 25 patients. AJR Am J Roentgenol 152(6):1179–1182PubMed
12.
Glimp RA, Bayer AS (1983) Pulmonary aspergilloma. Diagnostic and therapeutic considerations. Arch Intern Med 143(2):303–308PubMedCrossRef
13.
Hance AJ, Basset F, Saumon G et al (1986) Smoking and interstitial lung disease. The effect of cigarette smoking on the incidence of pulmonary histiocytosis X and sarcoidosis. Ann N Y Acad Sci 465:643–656PubMedCrossRef
14.
Valeyre D, Soler P, Clerici C et al (1988) Smoking and pulmonary sarcoidosis: effect of cigarette smoking on prevalence, clinical manifestations, alveolitis, and evolution of the disease. Thorax 43(7):516–524PubMedCrossRef
15.
Hanley ME, King TE Jr, Schwarz MI et al (1991) The impact of smoking on mechanical properties of the lungs in idiopathic pulmonary fibrosis and sarcoidosis. Am Rev Respir Dis 144(5):1102–1106PubMed
16.
Peros-Golubicic T, Ljubic S (1995) Cigarette smoking and sarcoidosis. Acta Med Croatica 49(4–5):187–193PubMed
17.
Pfeifer AK, Lange P (2006) Pulmonary consequences of marijuana smoking. Ugeskr Laeger 168(18):1743–1746PubMed
18.
Kagen SL, Kurup VP, Sohnle PG et al (1983) Marijuana smoking and fungal sensitization. J Allergy Clin Immunol 71(4):389–393PubMedCrossRef
19.
Kagen SL (1981) Aspergillus: an inhalable contaminant of marijuana. N Engl J Med 304(8):483–484PubMed
20.
21.
Centeno-Lima S, de Lacerda JM, do Carmo JA et al (2002) Follow-up of anti-Aspergillus IgG and IgA antibodies in bone marrow transplanted patients with invasive aspergillosis. J Clin Lab Anal 16(3):156–162PubMedCrossRef
22.
Sole A, Salavert M (2009) Fungal infections after lung transplantation. Curr Opin Pulm Med 15(3):243–253PubMedCrossRef
23.
Bergeron A, Belle A, Sulahian A et al (2010) Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies. Chest 137(2):410–415PubMedCrossRef
24.
Jennings TS, Hardin TC (1993) Treatment of aspergillosis with itraconazole. Ann Pharmacother 27(10):1206–1211PubMed
25.
Campbell JH, Winter JH, Richardson MD et al (1991) Treatment of pulmonary aspergilloma with itraconazole. Thorax 46(11):839–841PubMedCrossRef
26.
De Beule K, De Doncker P, Cauwenbergh G et al (1988) The treatment of aspergillosis and aspergilloma with itraconazole, clinical results of an open international study (1982–1987). Mycoses 31(9):476–485PubMedCrossRef
27.
Dupont B (1990) Itraconazole therapy in aspergillosis: study in 49 patients. J Am Acad Dermatol 23(3 Pt 2):607–614PubMedCrossRef
28.
Soltanzadeh H, Wychulis AR, Sadr F et al (1977) Surgical treatment of pulmonary aspergilloma. Ann Surg 186(1):13–16PubMedCrossRef
29.
Guerra M, Santos N, Miranda J et al (2008) Surgical management of pulmonary aspergilloma. Rev Port Cir Cardiotorac Vasc 15(3):135–138PubMed
30.
Chen JC, Chang YL, Luh SP et al (1997) Surgical treatment for pulmonary aspergilloma: a 28 year experience. Thorax 52(9):810–813PubMedCrossRef
31.
Brik A, Salem AM, Kamal AR et al (2008) Surgical outcome of pulmonary aspergilloma. Eur J Cardiothorac Surg 34(4):882–885PubMedCrossRef
32.
Caidi M, Kabiri H, Al Aziz S et al (2006) Surgical treatment of pulmonary aspergilloma. 278 cases. Presse Med 35(12 Pt 1):1819–1824PubMedCrossRef
33.
Camuset J, Nunes H, Dombret MC et al (2007) Treatment of chronic pulmonary aspergillosis by voriconazole in nonimmunocompromised patients. Chest 131(5):1435–1441PubMedCrossRef
34.
Felton TW, Baxter C, Moore CB et al (2010) Efficacy and safety of posaconazole for chronic pulmonary aspergillosis. Clin Infect Dis 51(12):1383–1391PubMedCrossRef
35.
Lee KS, Kim HT, Kim YH et al (1993) Treatment of hemoptysis in patients with cavitary aspergilloma of the lung: value of percutaneous instillation of amphotericin B. AJR Am J Roentgenol 161(4):727–731PubMed
36.
Rumbak M, Kohler G, Eastrige C et al (1996) Topical treatment of life threatening haemoptysis from aspergillomas. Thorax 51(3):253–255PubMedCrossRef
37.
Kaplan J, Johns CJ (1979) Mycetomas in pulmonary sarcoidosis: non-surgical management. Johns Hopkins Med J 145(4):157–161PubMed
38.
Idali F, Wikén M, Wahlström J et al (2006) Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. Eur Respir J 27(3):451–459PubMedCrossRef
39.
Chaudhary N, Staab JF, Marr KA (2010) Healthy human T-cell responses to Aspergillus fumigatus antigens. PLoS One 5(2):e9036PubMedCrossRef
40.
Judson MA (2009) Allergic bronchopulmonary aspergillosis after infliximab therapy for sarcoidosis: a potential mechanism related to T-helper cytokine balance. Chest 135(5):1358–1359PubMedCrossRef
Metadata
Title
Aspergillus Lung Disease in Patients with Sarcoidosis: A Case Series and Review of the Literature
Authors
Tahuanty A. Pena
Ayman O. Soubani
Lobelia Samavati
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Lung / Issue 2/2011
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-011-9280-9

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