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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 01-06-2018 | Original Paper

Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder

Authors: Annegret Krause-Utz, Dorina Winter, Friederike Schriner, Chui-De Chiu, Stefanie Lis, Philip Spinhoven, Martin Bohus, Christian Schmahl, Bernet M. Elzinga

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 4/2018

Abstract

Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the context of a working memory task in BPD. We aimed to investigate whole-brain activity and amygdala functional connectivity (FC) during an Emotional Working Memory Task (EWMT) after dissociation induction in un-medicated BPD patients compared to healthy controls (HC). Using script-driven imagery, dissociation was induced in 17 patients (‘BPD_D’), while 12 patients (‘BPD_N’) and 18 HC were exposed to neutral scripts during fMRI. Afterwards, participants performed the EWMT with neutral vs. negative IAPS pictures vs. no distractors. Main outcome measures were behavioral performance (reaction times, errors) and whole-brain activity during the EWMT. Psychophysiological interaction analysis was used to examine amygdala connectivity during emotional distraction. BPD patients after dissociation induction showed overall WM impairments, a deactivation in bilateral amygdala, and lower activity in left cuneus, lingual gyrus, and posterior cingulate than BPD_N, along with stronger left inferior frontal gyrus activity than HC. Furthermore, reduced amygdala FC with fusiform gyrus and stronger amygdala FC with right middle/superior temporal gyrus and left inferior parietal lobule was observed in BPD_D. Findings suggest that dissociation affects reactivity to emotionally salient material and WM. Altered activity in areas associated with emotion processing, memory, and self-referential processes may contribute to dissociative states in BPD.

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Title: Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder
Authors: Annegret Krause-Utz
Dorina Winter
Friederike Schriner
Chui-De Chiu
Stefanie Lis
Philip Spinhoven
Martin Bohus
Christian Schmahl
Bernet M. Elzinga
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 4/2018
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-017-0806-x

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Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder

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