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European Archives of Psychiatry and Clinical Neuroscience

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01-09-2015 | Original Paper

Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task

Authors: Alejandro Bachiller, Alba Lubeiro, Álvaro Díez, Vanessa Suazo, Cristina Domínguez, José A. Blanco, Marta Ayuso, Roberto Hornero, Jesús Poza, Vicente Molina

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 6/2015

Abstract

The analysis of the interaction between novelty and relevance may be of interest to test the aberrant salience hypothesis of schizophrenia (SCH). In comparison with other neuroimaging techniques, such as functional magnetic resonance imaging, electroencephalography (EEG) provides high temporal resolution. Therefore, EEG is useful to analyze transient dynamics in neural activity, even in the range of milliseconds. In this study, EEG activity from 31 patients with SCH and 38 controls was analyzed using Shannon spectral entropy (SE) and median frequency (MF). The aim of the study was to quantify differences between distractor (i.e., novelty) and target (i.e., novelty and relevance) tones in an auditory oddball paradigm. Healthy controls displayed a larger SE decrease in response to target stimulus than in response to distractor tones. SE decrease was accompanied by a significant and widespread reduction of MF (i.e., a significant slowing of EEG activity). In comparison with controls, patients showed a significant reduction of changes in SE in response to both target and distractor tones. These differences were also observed in patients that only received a minimal treatment prior to EEG recording. Furthermore, significant changes in SE were inversely correlated to positive and total symptoms severity for SCH patients. Our findings support the notion that SCH is associated with a reduced response to both novelty and relevance during an auditory P300 task.

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Title: Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task
Authors: Alejandro Bachiller
Alba Lubeiro
Álvaro Díez
Vanessa Suazo
Cristina Domínguez
José A. Blanco
Marta Ayuso
Roberto Hornero
Jesús Poza
Vicente Molina
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 6/2015
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-014-0525-5

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Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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