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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 3/2013

01-04-2013 | Original Paper

Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa

Authors: Jacqueline Hoare, Jenny Westgarth-Taylor, Jean-Paul Fouche, Marc Combrinck, Bruce Spottiswoode, Dan J. Stein, John A. Joska

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2013

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Abstract

HIV-associated dementia (HAD) is a serious neuropsychiatric disorder affecting people with AIDS. Host genotype may affect the pathogenesis of HIV in the central nervous system (CNS). One gene relevant to the individual variation in acquiring HAD may be Apolipoprotein E (ApoE). We aimed to investigate the relationship of ApoE genotype to neuropsychological function and white matter integrity of the corpus callosum in a region of interest a priori analysis of HIV-positive subjects with clade C HIV. Forty-five subjects underwent ApoE genotyping, neuropsychological testing, and diffusion tensor imaging (DTI). Subjects (n = 24) with at least one ε4 allele when compared to subjects with no ε4 allele (n = 19) had significantly decreased immediate and delayed recall on the Hopkins Verbal Learning test (p = 0.05) and significantly decreased fractional anisotrophy in the corpus callosum (p = 0.007). These data indicate that the ε4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects.
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Metadata
Title
Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa
Authors
Jacqueline Hoare
Jenny Westgarth-Taylor
Jean-Paul Fouche
Marc Combrinck
Bruce Spottiswoode
Dan J. Stein
John A. Joska
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2013
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-012-0341-8

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