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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 3/2013

01-04-2013 | Original Paper

The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD

Authors: Gustavo Lucena Kortmann, Verônica Contini, Guilherme Pinto Bertuzzi, Nina Roth Mota, Diego Luiz Rovaris, Vanessa Rodrigues Paixão-Côrtes, Leandro Leal de Lima, Eugenio Horacio Grevet, Carlos Alberto Iglesias Salgado, Eduardo Schneider Vitola, Luis Augusto Rohde, Paulo Belmonte-de-Abreu, Claiton Henrique Dotto Bau

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2013

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) affects approximately 5 % of school-aged children and 2.5 % of adults. Genetic studies in ADHD have pointed to genes in different neurobiological systems, with relatively small individual effects. The mineralocorticoid receptor is the main receptor involved in the initial triggering of stress response. Therefore, its encoding gene (NR3C2) is a candidate for psychiatric disorder studies, including ADHD, and behavioral phenotypes. There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. We investigated the possible role of the mineralocorticoid receptor gene in the symptom dimensions and susceptibility to persistent ADHD. We compared genotype and allele frequencies in 478 adult patients with ADHD and 597 controls and symptom dimensions in 449 patients and 132 controls. Diagnoses were based on the DSM-IV criteria. ADHD symptom dimensions were investigated with SNAP-IV for ADHD severity and Barkley scales for severity and impairment. Carriers of the Val allele presented higher inattention, hyperactivity/impulsivity and impairment scores, while genotype and allele frequencies did not differ between patients and controls. These results are consistent with a possible link between genetic variations in the HPA axis and inattention and hyperactivity measures.
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Metadata
Title
The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD
Authors
Gustavo Lucena Kortmann
Verônica Contini
Guilherme Pinto Bertuzzi
Nina Roth Mota
Diego Luiz Rovaris
Vanessa Rodrigues Paixão-Côrtes
Leandro Leal de Lima
Eugenio Horacio Grevet
Carlos Alberto Iglesias Salgado
Eduardo Schneider Vitola
Luis Augusto Rohde
Paulo Belmonte-de-Abreu
Claiton Henrique Dotto Bau
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2013
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-012-0321-z

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