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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 01-12-2011 | Original Paper

Adult attention deficit hyperactivity disorder is associated with migraine headaches

Authors: Ole Bernt Fasmer, Anne Halmøy, Ketil Joachim Oedegaard, Jan Haavik

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 8/2011

Abstract

Attention deficit hyperactivity disorder (ADHD) is now recognized as a common disorder both in child and adult psychiatry. Adult patients with a diagnosis of ADHD (n = 572) and community controls (n = 675) responded to auto-questionnaires rating past and present symptoms of ADHD, co-morbid conditions, including migraine, treatment history and work status. The prevalence of migraine was significantly higher in the patient group compared to the controls (28.3% vs. 19.2%, P < 0.001, OR = 1.67, CI 1.28–2.17). The difference from controls was particularly marked for men (22.5% vs. 10.7%, P < 0.001, OR = 2.43, CI 1.51–3.90) but was also significant for women (34.4% vs. 24.9%, P = 0.008, OR = 1.58, CI 1.13–2.21). In both patients and controls, migraine was associated with symptoms of mood and anxiety disorders. These findings point to a co-morbidity of migraine with ADHD, and it is possible that these patients represent a clinical and biological subgroup of adult patients with ADHD.

Adler LA, Chua HC (2002) Management of ADHD in adults. J Clin Psychiatry 63(Suppl 12):29–35PubMed

Barkley RA (2006) Attention-deficit hyperactivity disorder. A handbook for diagnosis and treatment. The Guilford Press, N Y

Barkley RA, Fischer M, Smallish L, Fletcher K (2002) The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. J Abnorm Psychol 111:279–289PubMedCrossRef

Bitter I, Simon V, Bálint S, Mészáros A, Czobor P (2010) How do different diagnostic criteria, age and gender affect the prevalence of attention deficit hyperactivity disorder in adults? An epidemiological study in a Hungarian community sample. Eur Arch Psychiatry Clin Neurosci 260:287–296PubMedCrossRef

Karch S, Thalmeier T, Lutz J, Cerovecki A, Opgen-Rhein M, Hock B, Leicht G, Hennig-Fast K, Meindl T, Riedel M, Mulert C, Pogarell O (2010) Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. Eur Arch Psychiatry Clin Neurosci 260:427–440PubMedCrossRef

Kessler RC, Adler LA, Barkley R, Biederman J, Conners CK, Faraone SV, Greenhill LL, Jaeger S, Secnik K, Spencer T, Ustün TB, Zaslavsky AM (2005) Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication. Biol Psychiatry 57:1442–1451PubMedCrossRef

Halmøy A, Fasmer OB, Gillberg C, Haavik J (2009) Occupational outcome in adult ADHD: impact of symptom profile, co-morbid psychiatric problems and treatment: a cross-sectional study of 414 clinically diagnosed adult ADHD patients. J Atten Disord 13:75–87CrossRef

Heiervang E, Stormark KM, Lundervold AJ, Heimann M, Goodman R, Posserud MB, Ullebø AK, Plessen KJ, Bjelland I, Lie SA, Gillberg C (2007) Psychiatric disorders in Norwegian 8–10-year-olds: an epidemiological survey of prevalence, risk factors, and service use. J Am Acad Child Adolesc Psychiatry 46:438–447PubMedCrossRef

Biederman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. Lancet 366:237–248PubMedCrossRef

10.

Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942–948PubMedCrossRef

11.

Fayyad J, De Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, Lépine JP, Ormel J, Posada-Villa J, Zaslavsky AM, Jin R (2007) Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry 190:402–409PubMedCrossRef

12.

Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM (2006) The prevalence and correlates of adult ADHD in the United States: results from the national comorbidity survey replication. Am J Psychiatry 163:716–723PubMedCrossRef

13.

Hammerness P, Monuteaux MC, Faraone SV, Gallo L, Murphy H, Biederman J (2005) Reexamining the familial association between asthma and ADHD in girls. J Atten Disord 8:136–143PubMedCrossRef

14.

Cortese S, Angriman M, Maffeis C, Isnard P, Konofal E, Lecendreux M, Purper-Ouakil D, Vincenzi B, Bernardina BD, Mouren MC (2008) Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature. Crit Rev Food Sci Nutr 48:524–537PubMedCrossRef

15.

Davidoff RA (2002) Migraine: manifestations, pathogenesis, and management. Oxford University Press, N Y

16.

Fasmer OB, Akiskal HS, Kelsoe JR, Oedegaard KJ (2009) Clinical and pathophysiological relations between migraine and mood disorders. Curr Psychiatry Rev 5:93–109CrossRef

17.

Wessman M, Terwindt GM, Kaunisto MA, Palotie A, Ophoff RA (2007) Migraine: a complex genetic disorder. Lancet Neurol 6:521–532PubMedCrossRef

18.

Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313–1323PubMedCrossRef

19.

Fasmer OB (2001) The prevalence of migraine in patients with bipolar and unipolar depressive disorders. Cephalalgia 21:894–899PubMedCrossRef

20.

Fasmer OB, Oedegaard KJ (2001) Clinical characteristics of patients with major affective disorders and comorbid migraine. World J Biol Psychiatry 2:149–155PubMedCrossRef

21.

Low NC, Du Fort GG, Cervantes P (2003) Prevalence, clinical correlates, and treatment of migraine in bipolar disorder. Headache 43:940–949PubMedCrossRef

22.

Breslau N, Merikangas K, Bowden CL (1994) Comorbidity of migraine and major affective disorders. Neurology 44(Suppl 7):S17–S22PubMed

23.

Jette N, Patten S, Williams J, Becker W, Wiebe S (2008) Comorbidity of migraine and psychiatric disorders: a national population-based study. Headache 48:501–516PubMedCrossRef

24.

Oedegaard KJ, Greenwood TA, Lunde A, Fasmer OB, Akiskal HS, Kelsoe JR, NIMH Genetics Initiative Bipolar Disorder Consortium (2010) A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. J Affect Disord 122:14–26PubMedCrossRef

25.

Stam AH, de Vries B, Janssens AC, Vanmolkot KR, Aulchenko YS, Henneman P, Oostra BA, Frants RR, van den Maagdenberg AM, Ferrari MD, van Duijn CM, Terwindt GM (2010) Shared genetic factors in migraine and depression: evidence from a genetic isolate. Neurology 74:288–294PubMedCrossRef

26.

Halmøy A, Halleland H, Dramsdahl M, Bergsholm P, Fasmer OB, Haavik J (2010) Bipolar symptoms in adult attention deficit hyperactivity disorder: a cross-sectional study of 510 clinically diagnosed patients and 417 population-based controls. J Clin Psychiatry 71:48–57PubMedCrossRef

27.

Johansson S, Halleland H, Halmøy A, Jacobsen KK, Landaas ET, Dramsdahl M, Fasmer OB, Bergsholm P, Lundervold AJ, Gillberg C, Hugdahl K, Knappskog PM, Haavik J (2008) Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs. Am J Med Genet B Neuropsychiatr Genet 147B:1470–1475PubMedCrossRef

28.

Halleland H, Lundervold A, Halmøy A, Johansson S, Haavik J (2009) Association between Catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Am J Med Genet B Neuropsychiatr Genet 150B:403–410PubMedCrossRef

29.

Ward MF, Wender PH, Reimherr FW (1993) The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150:885–890PubMed

30.

Adler LA, Spencer T, Faraone SV, Kessler RC, Howes MJ, Biederman J, Secnik K (2006) Validity of pilot adult ADHD self-report scale (ASRS) to rate adult ADHD symptoms. Ann Clin Psychiatry 18:145–148PubMedCrossRef

31.

Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E, Howes MJ, Jin R, Secnik K, Spencer T, Ustun TB, Walters EE (2005) The World health organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general population. Psychol Med 35:245–256PubMedCrossRef

32.

Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE Jr, Lewis L, McElroy SL, Post RM, Rapport DJ, Russell JM, Sachs GS, Zajecka J (2000) Development and validation of a screening instrument for bipolar spectrum disorder: the mood disorder questionnaire. Am J Psychiatry 157:1873–1875PubMedCrossRef

33.

Fossati A, Di Ceglie A, Acquarini E, Donati D, Donini M, Novella L, Maffei C (2001) The retrospective assessment of childhood attention deficit hyperactivity disorder in adults: reliability and validity of the Italian version of the Wender Utah Rating Scale. Compr Psychiatry 42:326–336PubMedCrossRef

34.

Rodríguez-Jiménez R, Ponce G, Monasor R, Jiménez-Giménez M, Pérez-Rojo JA, Rubio G, Jiménez Arriero, Palomo T (2001) Validation in the adult Spanish population of the Wender Utah Rating Scale for the retrospective evaluation in adults of attention deficit/hyperactivity disorder in childhood. Rev Neurol 33:138–144

35.

Hirschfeld RM, Holzer C, Calabrese JR, Weissman M, Reed M, Davies M, Frye MA, Keck P, McElroy S, Lewis L, Tierce J, Wagner KD, Hazard E (2003) Validity of the mood disorder questionnaire: a general population study. Am J Psychiatry 160:178–180PubMedCrossRef

36.

Mahmood T, Romans S, Silverstone T (1999) Prevalence of migraine in bipolar disorder. J Affect Disord 52:239–241PubMedCrossRef

37.

McIntyre RS, Konarski JZ, Wilkins K, Bouffard B, Soczynska JK, Kennedy SH (2006) The prevalence and impact of migraine headache in bipolar disorder: results from the Canadian community health survey. Headache 46:973–982PubMedCrossRef

38.

Fasmer OB, Oedegaard KJ (2005) Co-morbidity of migraine and affective disorders. In: Brown MR (ed) Focus on bipolar disorder research. Nova Science, N Y, pp 59–74

39.

Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American migraine study II. Headache 41:646–657PubMedCrossRef

40.

Lipton RB, Bigal ME (2005) The epidemiology of migraine. Am J Med 118(Suppl 1):3S–10SPubMed

41.

Bigal ME, Liberman JN, Lipton RB (2006) Age-dependent prevalence and clinical features of migraine. Neurology 67:246–251PubMedCrossRef

42.

Hagen K, Zwart JA, Vatten L, Stovner LJ, Bovim G (2000) Prevalence of migraine and non-migrainous headache–head-HUNT: a large population- based study. Cephalalgia 20:900–906PubMedCrossRef

43.

Kececi H, Dener S, Analan E (2003) Co-morbidity of migraine and major depression in the Turkish population. Cephalalgia 23:271–275PubMedCrossRef

44.

van de Ven RC, Kaja S, Plomp JJ, Frants RR, van den Maagdenberg AM, Ferrari MD (2007) Genetic models of migraine. Arch Neurol 64:643–646PubMedCrossRef

45.

Merikangas KR, Stevens DE (1997) Comorbidity of migraine and psychiatric disorders. Neurol Clin 15:115–123PubMedCrossRef

46.

Oedegaard KJ, Neckelmann D, Mykletun A, Dahl AA, Zwart JA, Hagen K, Fasmer OB (2006) Migraine with and without aura: association with depression and anxiety disorder in a population-based study. The HUNT study. Cephalalgia 26:1–6PubMedCrossRef

47.

Wilens TE, Biederman J, Wozniak J, Gunawardene S, Wong J, Monuteaux M (2003) Can adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adults. Biol Psychiatry 54:1–8PubMedCrossRef

48.

Goodwin FK, Jamison KR (2007) Manic-depressive illness. Oxford University Press, N Y

49.

McElroy SL, Soutullo CA, Beckman DA, Taylor P Jr, Keck PE Jr (1998) DSM-IV intermittent explosive disorder: a report of 27 cases. J Clin Psychiatry 59:203–210PubMedCrossRef

50.

Mulder EJ, Linssen WH, Passchier J, Orlebeke JF, de Geus EJ (1999) Interictal and postictal cognitive changes in migraine. Cephalalgia 19:557–565PubMedCrossRef

51.

Ravishankar N, Demakis GJ (2007) The neuropsychology of migraine. Dis Mon 53:156–161PubMedCrossRef

52.

Schmitz N, Arkink EB, Mulder M, Rubia K, Admiraal-Behloul F, Schoonman GG, Kruit MC, Ferrari MD, van Buchem MA (2008) Frontal lobe structure and executive function in migraine patients. Neurosci Lett 440:92–96PubMedCrossRef

53.

Peroutka SJ (1997) Dopamine and migraine. Neurology 49:650–656PubMed

54.

Emilien G, Maloteauw J-M, Geurts M, Hoogenberg K, Cragg S (1999) Dopamine receptors: physiological understanding to therapeutic intervention potential. Pharmacol Ther 84:133–156PubMedCrossRef

55.

Dunlop BW, Nemeroff CB (2007) The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 64:327–337PubMedCrossRef

56.

Oedegaard KJ, Greenwood TA, Johansson S, Jacobsen KK, Halmoy A, Fasmer OB, Akiskal HS, Bipolar Genome Study (BiGS), Haavik J, Kelsoe JR (2010) A genome-wide association study of bipolar disorder and co-morbid migraine. Genes Brain Behav 9:673–680

57.

Gervil M, Ulrich V, Olesen J, Russell MB (1998) Screening for migraine in the general population: validation of a simple questionnaire. Cephalalgia 18:342–348PubMedCrossRef

58.

Rasmussen BK, Jensen R, Olesen J (1991) Questionnaire versus clinical interview in the diagnosis of headache. Headache 31:290–295PubMedCrossRef

59.

Russell MB, Rasmussen BK, Thorvaldsen P, Olesen J (1995) Prevalence and sex-ratio of the subtypes of migraine. Int J Epidemiol 24:612–618PubMedCrossRef

60.

Dahlöf C, Linde M (2001) One-year prevalence of migraine in Sweden: a population-based study in adults. Cephalalgia 21:664–671PubMedCrossRef

61.

Linde M, Dahlöf C (2004) Attitudes and burden of disease among self-considered migraineurs: a nation-wide population-based survey in Sweden. Cephalalgia 24:455–465PubMedCrossRef

Title: Adult attention deficit hyperactivity disorder is associated with migraine headaches
Authors: Ole Bernt Fasmer
Anne Halmøy
Ketil Joachim Oedegaard
Jan Haavik
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 8/2011
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-011-0203-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Adult attention deficit hyperactivity disorder is associated with migraine headaches

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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