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European Archives of Oto-Rhino-Laryngology

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01-05-2019 | Rhinosinusitis | Rhinology

Does procalcitonin have a role in the pathogenesis of nasal polyp?

Authors: Suat Bilici, Zehra Cinar, Ozgur Yigit, Mustafa Cakir, Enes Yigit, Hafize Uzun

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2019

Abstract

Purpose

The aim of this study is to investigate serum and tissue procalcitonin (PCT) levels in patients with nasal polyps.

Methods

The study was designed to be prospectively controlled and included 26 patients chronic rhinosinusitis with nasal polyp (CRSwNP) endoscopically diagnosed and as a control group 25 chronic rhinosinusitis without nasal polyp (CRSsNP). NP specimens, nasal mucosal tissue and venous blood samples of both groups were collected and PCT levels determined by Elisa method. The results were compared statistically.

Results

Serum PCT values were 1319.5 pg/mL in the NP group and 818.8 pg/mL in the control group. The difference between the groups was statistically significant (p = 0.0001). In the NP group, the average PCT value of the polyp tissue was 1521.5 pg/gr, while the mean PCT value of the control group in the nasal mucosa was 414.6 pg/gr. There was a statistically significant difference between the groups (p = 0.0001). The tissue cut-off value of PCT 750 was significant [area under curve 0.940 (0.863–1.00)]. Serum PCT 950 cut-off value was significant [area under curve 0.860 (0.748–0.972)] activity (CI: 95%).

Conclusions

This is the first study of its kind to objectively examine PCT in the polyp and serum of CRSwNP patients. PCT may serve as a diagnostic biomarker in nasal polyps.

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Title: Does procalcitonin have a role in the pathogenesis of nasal polyp?
Authors: Suat Bilici
Zehra Cinar
Ozgur Yigit
Mustafa Cakir
Enes Yigit
Hafize Uzun
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keyword: Rhinosinusitis
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05326-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Does procalcitonin have a role in the pathogenesis of nasal polyp?

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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