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European Archives of Oto-Rhino-Laryngology

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Open Access 01-04-2019 | Metastasis | Head & Neck

Management of clinically N0 neck in oropharyngeal carcinoma

Authors: Lauri Jouhi, Timo Atula, Antti Mäkitie, Harri Keski-Säntti

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2019

Abstract

Purpose

Only a minority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed without regional metastasis (cN0). Studies focusing on the management of cN0 neck in OPSCC are scarce.

Methods

We reviewed all OPSCC patients treated at our institution with cN0 neck between 2000 and 2009. The treatment of neck and pattern of regional control was analyzed. Median follow-up was 5 years (range 3.5–9.0) or until death.

Results

Of the total 313 OPSCC patients treated within the period, 56 (18%) presented with cN0 neck. Of them, 51 (91%) received completed treatment with curative intent: 46 (90%) underwent elective neck treatment with either neck dissection ± (chemo)radiotherapy (C)RT (n = 23) or (C)RT (n = 23). A regional recurrence occurred in three patients (6%) and they all had a p16-negative soft palate midline primary tumor. Two of these patients had received RT on the neck.

Conclusions

While the overall prognosis of OPSCC is generally favorable and regional recurrences are infrequent, soft palate tumors, that are usually p16 negative, may form an subgroup warranting more aggressive treatment despite the clinical appearance of early stage.

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Title: Management of clinically N0 neck in oropharyngeal carcinoma
Authors: Lauri Jouhi
Timo Atula
Antti Mäkitie
Harri Keski-Säntti
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keywords: Metastasis
Neck Dissection
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05314-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Management of clinically N0 neck in oropharyngeal carcinoma

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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