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European Archives of Oto-Rhino-Laryngology

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01-02-2018 | Head and Neck

Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis

Authors: Ting-Ting Xiao, Xian Li, Ying Xu, Yong Li

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2018

Abstract

Aim

To evaluate the possible relevance of the IL-18-137 G>C (rs187238), IL-18-607 C>A (rs1946518) and IL-4-590 C>T (rs2243250) polymorphisms to the genetic susceptibility of head and neck cancer.

Methods

Data were retrieved from PubMed, EMBASE, Web of Science and CNKI databases, and the results were independently analysed by two reviewers using Stata 14.0 software.

Results

After searching for and assessing the literature, a total of thirteen studies involving 2,959 patients newly diagnosed as head and neck cancer and 3,622 controls from healthy donors were analysed. The results suggested that a strong relationship between patients and healthy controls was observed in the IL-18-137 G>C polymorphism in consistence with the result (CC vs. GG + GC: OR = 1.63, P = 0.004; CC vs. GG: OR = 1.82, P = 0.001). When stratified by cancer type, ethnicity and the source of control samples, significant and elevated risks were obtained in the genetic susceptibility to Asian patients with NPC in all genetic models and in those studies using the PCR-RFLP test method. In addition, comparable results were obtained for the IL-18-607 C>A polymorphism, especially for Asian patients with NPC.

Conclusions

It should be a potential association between IL-18 variants and nasopharyngeal carcinoma. Furthermore, IL-18 gene variants might be considered as a critical role in predicting the occurrence of nasopharyngeal carcinoma in Asian population. However, the IL-4-590 C>T polymorphism does not influence the development of head and neck cancer.

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Title: Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis
Authors: Ting-Ting Xiao
Xian Li
Ying Xu
Yong Li
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-017-4820-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis

Abstract

Aim

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Aim

Methods

Results

Conclusions

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