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European Archives of Oto-Rhino-Laryngology

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01-03-2017 | Rhinology

Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods

Authors: Sophia C. Poletti, Islam Batashev, Jens Reden, Thomas Hummel

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2017

Abstract

Limited olfactory improvement after topical steroid therapy in chronic rhinosinusitis (CRS) patients might result from restricted drug access to the olfactory cleft. The aim of our study was to investigate the difference between two methods to topically administer steroids with respect to olfaction: (1) conventional nasal spray and (2) a device using pressure and vibration to distribute steroid aerosol endonasally. A prospective study was performed in patients with olfactory impairment due to chronic rhinosinusitis with and without nasal polyps. While the first group used the conventional dexamethasone nasal spray, the second group used the device over a period of 12 days. Olfactory testing was done at 0, 2, and 8 weeks using Sniffin’ Sticks test. A significant olfactory improvement was found after 2 weeks of treatment with either steroid (p = 0.005). However, there was no significant difference between the different methods of steroid application. There is a significant olfactory improvement in CRS patients following topical dexamethasone therapy, but no obvious superiority of one of the two ways to administer the steroid.

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Title: Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods
Authors: Sophia C. Poletti
Islam Batashev
Jens Reden
Thomas Hummel
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4341-6

ACC 2024 Congress

Springer Medicine

Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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