Top

European Archives of Oto-Rhino-Laryngology

Published in:

Open Access 01-02-2017 | Head and Neck

Feasibility of electronic nose technology for discriminating between head and neck, bladder, and colon carcinomas

Authors: R. M. G. E. van de Goor, N. Leunis, M. R. A. van Hooren, E. Francisca, A. Masclee, B. Kremer, K. W. Kross

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2017

Abstract

Electronic nose (e-nose) technology has the potential to detect cancer at an early stage and can differentiate between cancer origins. Our objective was to compare patients who had head and neck squamous cell carcinoma (HNSCC) with patients who had colon or bladder cancer to determine the distinctive diagnostic characteristics of the e-nose. Feasibility study An e-nose device was used to collect samples of exhaled breath from patients who had HNSCC and those who had bladder or colon cancer, after which the samples were analyzed and compared. One hundred patients with HNSCC, 40 patients with bladder cancer, and 28 patients with colon cancer exhaled through an e-nose for 5 min. An artificial neural network was used for the analysis, and double cross-validation to validate the model. In differentiating HNSCC from colon cancer, a diagnostic accuracy of 81 % was found. When comparing HNSCC with bladder cancer, the diagnostic accuracy was 84 %. A diagnostic accuracy of 84 % was found between bladder cancer and colon cancer. The e-nose technique using double cross-validation is able to discriminate between HNSCC and colon cancer and between HNSCC and bladder cancer. Furthermore, the e-nose technique can distinguish colon cancer from bladder cancer.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87–108. doi:10.3322/caac.21262 CrossRefPubMed

McGuire S (2016) World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr Int Rev J 7(2):418–419. doi:10.3945/an.116.012211

Hirsch FR, Franklin WA, Gazdar AF, Bunn PA (2001) Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 7(1):5–22PubMed

Amann A, Mochalski P, Ruzsanyi V, Broza YY, Haick H (2014) Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties. J Breath Res 8(1):016003–016003. doi:10.1088/1752-7155/8/1/016003

Wilson AD, Baietto M (2009) Applications and advances in electronic-nose technologies. Sensors (Basel, Switzerland) 9(7):5099–5148. doi:10.3390/s90705099

de Boer NKH, de Meij TGJ, Oort FA, Ben Larbi I, Mulder CJJ, van Bodegraven AA, van der Schee MP (2014) The scent of colorectal cancer: detection by volatile organic compound analysis. Clin Gastroenterol Hepatol 12(7):1085–1089. doi:10.1016/j.cgh.2014.05.005 CrossRefPubMed

Shafiek H, Fiorentino F, Merino JL, López C, Oliver A, Segura J, de Paul I, Sibila O, Agustí A, Cosío BG (2015) Using the electronic nose to identify airway infection during COPD exacerbations. PLoS One 10(9):e0135199. doi:10.1371/journal.pone.0135199 CrossRefPubMedPubMedCentral

MontuschiPaolo P (2010) Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma. Chest 137(4):790–796CrossRef

D’Amico A, Pennazza G, Santonico M, Martinelli E, Roscioni C, Galluccio G, Paolesse R, Di Natale C (2010) An investigation on electronic nose diagnosis of lung cancer. Lung Cancer 68(2):170–176. doi:10.1016/j.lungcan.2009.11.003 CrossRefPubMed

10.

Leunis N, Boumans M-L, Kremer B, Din S, Stobberingh E, Kessels AGH, Kross KW (2014) Application of an electronic nose in the diagnosis of head and neck cancer. Laryngoscope 124(6):1377–1381. doi:10.1002/lary.24463 CrossRefPubMed

11.

van Hooren MRA, Leunis N, Brandsma DS, Dingemans A-MC, Kremer B, Kross KW (2016) Differentiating head and neck carcinoma from lung carcinoma with an electronic nose: a proof of concept study. Eur Arch Oto-Rhino-Laryngol 1–7. doi:10.1007/s00405-016-4038-x

12.

Rettig EM, D’Souza G (2015) Epidemiology of head and neck cancer. Surg Oncol Clin N Am 24(3):379–396. doi:10.1016/j.soc.2015.03.001 CrossRefPubMed

13.

Amal H, Leja M, Funka K, Lasina I, Skapars R, Sivins A, Ancans G, Kikuste I, Vanags A, Tolmanis I, Kirsners A, Kupcinskas L, Haick H (2016) Breath testing as potential colorectal cancer screening tool. Int J Cancer 138(1):229–236. doi:10.1002/ijc.29701 CrossRefPubMed

14.

Gruber M, Tisch U, Jeries R, Amal H, Hakim M, Ronen O, Marshak T, Zimmerman D, Israel O, Amiga E, Doweck I, Haick H (2014) Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study. Br J Cancer 111(4):790–798. doi:10.1038/bjc.2014.361 CrossRefPubMedPubMedCentral

15.

Peng G, Hakim M, Broza YY, Billan S, Abdah-Bortnyak R, Kuten A, Tisch U, Haick H (2010) Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br J Cancer 103(4):542–551. doi:10.1038/sj.bjc.6605810 CrossRefPubMedPubMedCentral

16.

Andre K, Schraub S, Mercier M, Bontemps P (1995) role of alcohol and tobacco in the aetiology of head and neck cancer: a case-control study in the doubs region of France. Eur J Cancer B Oral Oncol 31(5):301–309. doi:10.1016/0964-1955(95)00041-0 CrossRef

Title: Feasibility of electronic nose technology for discriminating between head and neck, bladder, and colon carcinomas
Authors: R. M. G. E. van de Goor
N. Leunis
M. R. A. van Hooren
E. Francisca
A. Masclee
B. Kremer
K. W. Kross
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4320-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Feasibility of electronic nose technology for discriminating between head and neck, bladder, and colon carcinomas

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2017

Palato-maxillary reconstruction by the angular branch-based tip of scapula free flap

Histopathological evaluation and long-term results of soft tissue preservation technique in cholesteatoma surgery

Work-up of globus: assessing the benefits of neck ultrasound and videofluorography

Investigation of sinonasal anatomy via low-dose multidetector CT examination in chronic rhinosinusitis patients with higher risk for perioperative complications

Olfactory dysfunction in acute rhinosinusitis: intranasal sodium hyaluronate as adjuvant treatment

Cross-cultural adaptation and validation of the SNOT-22 into Italian