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European Archives of Oto-Rhino-Laryngology

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01-01-2017 | Laryngology

The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia

Authors: L. Staníková, J. Šatanková, H. Kučová, R. Walderová, K. Zeleník, Pavel Komínek

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2017

Abstract

The aim of this study was to investigate whether observing microvascular changes by narrow-band imaging (NBI) endoscopy in the area surrounding leukoplakia is sufficient for discriminating between benign and malignant patterns of vocal cord leukoplakia. A total of 282 patients were investigated using white-light high-definition TV laryngoscopy and NBI endoscopy from 6/2013 to 8/2015, and 63 patients with a primary case of laryngeal leukoplakia were enrolled. Patients were divided into two groups based on leukoplakia with surrounding malignant intraepithelial papillary capillary loops (group I; 26/63) and leukoplakia with a surrounding benign vascular network (group II; 37/63), both by NBI endoscopy. All 63 patients were evaluated by blinded histological examination, and results were compared with NBI optical biopsy. Carcinoma in situ or invasive squamous cell carcinoma was confirmed in 22/26 cases (84.6 %) in group I. Hyperkeratosis or low-grade dysplasia was confirmed histologically in 31/37 (83.8 %) and squamous cell carcinoma in 2/37 (5.4 %) cases in group II. Accordance of NBI endoscopy and histopathological features of vocal cord leukoplakia lesions was statistically significant (kappa index 0.77, p < 0.001), with a sensitivity of 88.0 % (95 % CI 67.8–97.5 %) and specificity of 89.5 % (95 % CI 71.2–97.1 %). NBI is convenient for improving evaluation of laryngeal leukoplakias based on optic prehistological diagnosis. The close accordance between NBI features and histological results suggests that a negative NBI endoscopy may be an indication for long-term endoscopy follow-up without histological evaluation.

Isenberg JS, Crozier DL, Dailey SH (2008) Institutional and comprehensive review of laryngeal leukoplakia. Ann Otol Rhinol Laryngol 117(1):74–79CrossRefPubMed

Frangez I, Gale N, Luzar B (1997) The interpretation of leukoplakia in laryngeal pathology. Acta Otolaryngol Suppl 527:142–144CrossRefPubMed

Lee DH, Yoon TM, Lee JK, Lim SC (2015) Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia. Eur Arch Otorhinolaryngol 272:1719–1724CrossRefPubMed

Kleinsasser O (1963) Die klassification und differential diagnose der epithelyperplasien der kehlkopfschleimhaut auf grund histomorphologischer merkmale (II). Zschr Laryng Rhinol 42:339

Malzahn K, Dreyer T, Glanz H et al (2002) Autofluorescence endoscopy in the diagnosis of early laryngeal cancer and its precursor lesions. Laryngoscope 112:488–493CrossRefPubMed

Ricci G, Molini E, Faralli M, Simoncelli C (2003) Retrospective study on precancerous laryngeal lesions: long-term follow-up. Acta Otorhinolaryngol Ital 23(5):362–367PubMed

Young CK, Lin WN, Lee LY, Lee LA, Hsin LJ, Liao CT, Li HY, Chen IH, Fang TJ (2014) Laryngoscopic characteristics in vocal leukoplakia: inter-rater reliability and correlation with histology grading. Laryngoscope 125(2):E62–E66CrossRefPubMed

Lukes P, Zabrodsky M, Lukesova E, Chovanec M, Astl J, Betka J, Plzak J (2014) The role of NBI HDTV magnifying endoscopy in the prehistologic diagnosis of laryngeal papillomatosis and spinocellular cancer. Biomed Res Int. doi:10.1155/2014/285486 (article ID 285486, Epub 17 Jun 2014)

Ni XG, He S, Xu ZG, Gao L, Lu N, Yuan Z, Sq Lai, Zhang JM, Yi JL, Wang WL, Zhang L, Li XY, Wang GQ (2011) Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 125(3):288–296CrossRefPubMed

10.

Piazza C, Del Bon F, Peretti G, Nicolai P (2012) Narrow band imaging in endoscopic evaluation of the larynx. Curr Opin Otolaryngol Head Neck Surg 20:472–476CrossRefPubMed

11.

Lin YC, Wang WH, Lee KF et al (2012) Value of narrow band imaging endoscopy in early mucosal head and neck cancer. Head Neck 34(11):1574–1579. doi:10.1002/hed.21964 CrossRefPubMed

12.

Arens C, Piazza C, Andrea M, Dikkers FG, Tjon Pian Gi REA, Voigt-Zimmermann Z, Peretti G (2016) Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Otorhinolaryngol 73(5):1207–1214CrossRef

13.

Gale N, Michaels L, Luzar B, Poljak M, Zidar N, Fischinger J, Cardesa A (2009) Current review on squamous intraepithelial lesions of the larynx. Histopathology 54(6):639–656CrossRefPubMed

14.

Gallo A, De Vincentiis M, Della Rocca C, Moi R, Simonelli M, Minni A, Shaha AR (2001) Evolution of precancerous laryngeal lesions: a clinicopathological study with long-term follow-up on 259 patients. Head Neck 23:42–47CrossRef

15.

Bouquot JE, Gnepp DR (1991) Laryngeal precancer: a review of the literature commentary and comparison with oral leukoplakia. Head Neck 13(6):488–497CrossRefPubMed

16.

Yang SW, Lee YS, Chang LC (2013) Light sources used in evaluating oral leukoplakia: broadband white light versus narrowband imaging. Int J Oral Maxillofac Surg 42:693–701CrossRefPubMed

17.

Bartlett RS, Heckman WW, Isenberg J et al (2012) Genetic characterization of vocal fold lesions: leukoplakia and carcinoma. Laryngoscope 122(2):336–342CrossRefPubMedPubMedCentral

18.

Avila DD, D´Ávila J, Góis C et al (2014) Premalignant laryngeal lesions: twenty-year experience in specialized service. Int Arch Otorhinolaryngol 18:352–356CrossRefPubMedPubMedCentral

19.

Staníková L, Kučová H, Walderová R, Zeleník K, Šatanková J, Komínek P (2015) Value of narrow band imaging (NBI) in early diagnosis of laryngeal cancer. Klin Onkol 28(2):116–120CrossRefPubMed

20.

Yang SW, Lee YS, Chang LC et al (2012) Diagnostic significance of narrow-band imaging for detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral leukoplakia. Laryngoscope 122:2754–2761CrossRefPubMed

21.

Piazza C, Cocco D, De Benedetto L, Del Bon F, Nicolai P, Peretti G (2010) Narrow band imaging and high definition television in the assessment of laryngeal cancer: a prospective study on 279 patients. Eur Arch Otorhinolaryngol 267(3):409–414CrossRefPubMed

22.

Watanabe A, Taniguchi M, Tsujie H, Hosokawa M, Fujita M, Sasaki S (2009) The value of narrow band imaging for early detection of laryngeal cancer. Eur Arch Otorhinolaryngol 266(7):1017–1023CrossRefPubMed

Title: The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia
Authors: L. Staníková
J. Šatanková
H. Kučová
R. Walderová
K. Zeleník
Pavel Komínek
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4244-6

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The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia

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