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European Archives of Oto-Rhino-Laryngology

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01-07-2015 | Review Article

The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma

Authors: Federico Maria Gioacchini, Matteo Alicandri-Ciufelli, Giuseppe Magliulo, Corrado Rubini, Livio Presutti, Massimo Re

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2015

Abstract

The aim of this study was to determine the prognostic value of Ki-67 immunostaining in patients affected by laryngeal squamous cell carcinoma. A systematic review was carried out in a tertiary university referral center. An appropriate string was run on PubMed to retrieve articles dealing with Ki-67 immunohistochemical staining and laryngeal squamous cell carcinoma. A double cross-check was performed on citations and full-text articles by two investigators independently to review all manuscripts and perform a comprehensive quality assessment. Of 85 abstracts identified, 18 articles were included. These studies reported on 1,342 patients with histological confirmed diagnosis of laryngeal squamous cell carcinoma. Most studies showed a statistical association between Ki-67 immunohistochemical expression and at least one of the clinical and histopathological parameters considered by the authors. Overall the studies analyzed suggested that the tumoral proliferative index was statistically connected respectively with T stage (2/18), N stage (4/18), grading (6/18), disease-free survival (10/18) and overall survival (4/18). Our review strongly suggests that immunohistochemical staining of Ki-67 correlates with tumoral aggressiveness and worse prognosis in patients affected by laryngeal squamous cell carcinoma. Further high-quality prospective studies should be carried out to confirm our finding and determine the eventual differences between cancers of specific laryngeal subsites.

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Title: The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma
Authors: Federico Maria Gioacchini
Matteo Alicandri-Ciufelli
Giuseppe Magliulo
Corrado Rubini
Livio Presutti
Massimo Re
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2015
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3117-0

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The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma

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