Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-10-2014 | Rhinology

Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps

Authors: Hong Ouyang, Jie Cheng, Yajun Zheng, Jingdong Du

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2014

Abstract

Interleukin-31 (IL-31) is reported to be involved in Th2 cell-mediated diseases. However, the regulatory effect of IL-31 in the pathogenesis of nasal polyps (NPs) has not been understood. This study is aimed to determine whether IL-31 production is associated with Th2 cytokine levels and clinical severity in patients with NPs. Thirty patients with NPs and fifteen normal controls were included, and IL-31 production was determined by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The relationship between IL-31 expression and clinical severity was also evaluated. Besides, the effect of IL-31 on Th2 cytokine expression by polyp epithelial cells was investigated. We observed significantly enhanced IL-31 mRNA and protein level expression in NPs compared with normal control. IL-31+ cells were found to be positively correlated with clinical severity of NPs. Furthermore, we provided the direct evidence that IL-31 up-regulates Th2 cytokines expressed by polyp epithelial cells. Our results demonstrate that enhanced Th2 cytokine levels was correlated with IL-31 expression in NPs and provide a possible explanation for IL-31’s regulatory role in the pathogenesis of NPs.

Kramer MF, Rasp G (1999) Nasal polyposis: eosinophils and interleukin-5. Allergy 547:669–680CrossRef

Bachert C, Patou J, Van Cauwenberge P (2006) The role of sinus disease in asthma. Curr Opin Allergy Clin Immunol 6:29–36PubMedCrossRef

Mygind N, Dahl R, Bachert C (2000) Nasal polyposis, eosinophil dominated inflammation, and allergy. Thorax 55:S79–S83PubMedCentralPubMedCrossRef

Harlin SL, Ansel DG, Lane SR, Myers J, Kephart GM, Gleich GJ (1988) A clinical and pathologic study of chronic sinusitis: the role of the eosinophil. J Allergy Clin Immunol 81:867–875PubMedCrossRef

Stierna P, Carlsoo B (1990) Histopathological observations in chronic maxillary sinusitis. Acta Otolaryngol 110:450–458PubMedCrossRef

Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P et al (2006) Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61:1280–1289PubMedCrossRef

Claeys S, De Belder T, Holtappels G, Gevaert P, Verhasselt B, Van Cauwenberge P et al (2004) Macrophage mannose receptor in chronic sinus disease. Allergy 59:606–612PubMedCrossRef

Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R et al (2008) Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 121:1385–1392PubMedCentralPubMedCrossRef

Patadia M, Dixon J, Conley D, Chandra R, Peters A, Suh LA et al (2010) Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis. Am J Rhinol Allergy 24:11–16PubMedCentralPubMedCrossRef

10.

Tieu DD, Peters AT, Carter RT, Suh L, Conley DB, Chandra R et al (2010) Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. J Allergy Clin Immunol 125:667–675PubMedCentralPubMedCrossRef

11.

Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR et al (2004) Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 5:752–760PubMedCrossRef

12.

Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L et al (2006) IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 117:411–417PubMedCrossRef

13.

Chatopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H (2007) Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J Biol Chem 282:3014–3026CrossRef

14.

Okano M, Fujiwara T, Higaki T, Makihara S, Haruna T, Noda Y, Kanai K, Kariya S, Yasueda H, Nishizaki K (2011) Characterization of pollen antigen-induced IL-31 production by PBMCs in patients with allergic rhinitis. J Allergy Clin Immunol 127:277–279.e1-11PubMedCrossRef

15.

Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM et al (2008) SCF and IL-31 rather than IL-17 and BAFF are potential indicators in patients with allergic asthma. Allergy 63:327–332PubMedCrossRef

16.

Yu J-I, Han W-C, Yun K-J, Moon H-B, Oh G-J, Chae S-C (2012) Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma. Korean J Pathol 46:162–168PubMedCentralPubMedCrossRef

17.

Stott Bryony, Lavender Paul, Lehmann Sarah, Pennino Davide, Durham Stephen, Schmidt-Weber Carsten B (2013) Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation. J Allergy Clin Immunol 132:446–454PubMedCrossRef

18.

Fokkens W, Lund V, Mullol J (2007) European position paper on rhinosinusitis and nasal polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 20:1–136PubMed

19.

Hamilos DL, Leung DY, Wood R, Cunningham L, Bean DK, Yasruel Z et al (1995) Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 96:537–544PubMedCrossRef

20.

Bachert C, Gevaert P, Holtappels G, Cuvelier C, Van Cauwenberge P (2000) Nasal polyposis: from cytokines to growth. Am J Rhinol 14:279–290PubMedCrossRef

21.

Neis MM, Peters B, Dreuw A, Wenzel J, Bieber T, Mauch C et al (2006) Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol 118:930–937PubMedCrossRef

22.

Gambichler T, Kreuter A, Tomi NS, Othlinghaus N, Altmeyer P, Skrygan M (2008) Gene expression of cytokines in atopic eczema before and after ultraviolet al phototherapy. Br J Dermatol 158:1117–1120PubMedCrossRef

23.

Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ et al (2007) Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut 56:1257–1265PubMedCentralPubMedCrossRef

24.

Ip WK, Wong CK, Li ML, Li PW, Cheung PF, Lam CW (2007) Interleukin-31 induces cytokine and chemokine production from human bronchial epithelial cells through activation of mitogen-activated protein kinase signaling pathways: implications for the allergic response. Immunology 122:532–541PubMedCentralPubMedCrossRef

Title: Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps
Authors: Hong Ouyang
Jie Cheng
Yajun Zheng
Jingdong Du
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 10/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-2913-x

At a glance: The STEP trials

Springer Medicine

Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2014

Low prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs in Chinese patients with chronic rhinosinusitis

Deep neck space abscesses of dental origin: the impact of Streptococcus group Milleri

Gentamicin conditioning confers auditory protection against noise trauma

Staphylococcus aureus superantigens are associated with chronic rhinosinusitis with nasal polyps: a meta-analysis

Chondrosarcomas of the head and neck

Vasospasm of labyrinthine artery in cerebellopontine angle surgery: evidence brought by distortion-product otoacoustic emissions