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European Archives of Oto-Rhino-Laryngology

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01-05-2014 | Head and Neck

Two-year results of a prospective preventive swallowing rehabilitation trial in patients treated with chemoradiation for advanced head and neck cancer

Authors: Lisette van der Molen, Maya A. van Rossum, Coen R. N. Rasch, Ludi E. Smeele, Frans J. M. Hilgers

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2014

Abstract

The objective of the study was the assessment of the results of a prospective clinical trial with two preventive swallowing rehabilitation programs on the long-term side effects of chemoradiotherapy (CCRT) in advanced head and neck cancer patients. The study cohort consisted of 29 patients, randomized in two exercise groups: a standard (S) group receiving routine swallowing exercises (N = 14), and an experimental (E) group receiving swallowing exercises based on the TheraBite® Jaw Motion Rehabilitation System™ (N = 15). Assessment of functional changes was carried out with multidimensional outcome measures (e.g., videofluoroscopy, study-specific questionnaires) at four time points (pre-treatment, at 10 weeks, 1 year, and 2 years post-treatment). Overall, in the first year post-treatment many initial tumor- and treatment-related problems diminished significantly, except xerostomia (59 %). The only additional improvement at 2 years was that the overall weight significantly further increased (p = 0.000), however, without regaining baseline value. In the subgroup analysis according to exercise group, this difference was significant in the E-group only (p = 0.002). The same was the case for the subgroup analysis according to site of disease, with a significant weight gain in the ‘below the hyoid bone’ group only. This study shows that the overall functional problems at 1 and 2 years post-CCRT are limited. Both rehabilitation programs produce similar results, with a slight but significant benefit for the E-group in weight gain at 2 years, as also seen in the ‘below the hyoid bone’ group. Both rehabilitation programs applied are feasible and show good compliance despite the burdensome CCRT.

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Title: Two-year results of a prospective preventive swallowing rehabilitation trial in patients treated with chemoradiation for advanced head and neck cancer
Authors: Lisette van der Molen
Maya A. van Rossum
Coen R. N. Rasch
Ludi E. Smeele
Frans J. M. Hilgers
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2640-8

At a glance: The STEP trials

Springer Medicine

Two-year results of a prospective preventive swallowing rehabilitation trial in patients treated with chemoradiation for advanced head and neck cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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