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European Archives of Oto-Rhino-Laryngology

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01-05-2013 | Rhinology

TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis

Authors: Li Xie, Xiao-Nan Liang, Yan Deng, Xue Qin, Shan Li

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2013

Abstract

Previous evidence has indicated that the polymorphism of tumor necrosis factor-alpha (TNF-α) is a risk factor for various cancers, however, the association between TNF-α-308G/A polymorphism and nasopharyngeal carcinoma (NPC) remains controversial and ambiguous. The aim of this study is to clarify the association between TNF-α polymorphism and NPC using meta-analysis. A meta-analysis based on five eligible case–control studies involving 499 cases and 1,470 controls was carried out to summarize the data on the association between TNF-α-308G/A polymorphism and NPC risk. Odds ratios (OR) with 95 % confidence intervals (95 % CI) were used to assess the strength of this association in the fixed-effect model. The pooled analyses showed no significant association between TNF-α-308G/A polymorphism and NPC (AA vs. GG: OR = 1.38, P = 0.193; GA vs. GG: OR = 0.92, P = 0.585; GA + AA vs. GG: OR = 1.00, P = 0.972; AA vs. GA + GG: OR = 1.44, P = 0.138). We also categorized by geographic location (non-Asian or Asian) for subgroup analysis; the results also showed no significant association between TNF-α-308G/A polymorphism and NPC risk in all of the comparisons. No publication bias was observed in this study (t = −0.11, P = 0.918, 95 % CI = −4.893–4.559). No significant association was found between TNF-α-308G/A polymorphism and the risk for NPC.

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Title: TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis
Authors: Li Xie
Xiao-Nan Liang
Yan Deng
Xue Qin
Shan Li
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2276-0

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TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis

Abstract

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