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European Archives of Oto-Rhino-Laryngology

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01-12-2012 | Laryngology

The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis

Authors: S. Mikolajczak, G. Quante, S. Weissenborn, A. Wafaisade, U. Wieland, J. C. Lüers, J. P. Klussmann, D. Beutner

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2012

Abstract

Cidofovir is an antiviral agent used in the therapy of recurrent respiratory papillomatosis (RRP). In this study, we hypothesized that cidofovir is effective in decreasing the viral load of human papillomavirus (HPV). We established a type specific real-time PCR and measured HPV DNA loads. The course of viral load of HPV types 6 and 11 after repeated applications of cidofovir intralesionally was compared to the clinical outcome using a modified Derkay score. In 6 of the 8 (75 %) patients, we detected HPV 6. In 2 (25 %) patients, we detected HPV 11. In all of the patients, the viral load and the modified Derkay score decreased significantly during the treatment. We conclude that viral load of HPV can be monitored using the technique described here. Cidofovir in combination with surgical debulking reduces the viral load in patients with RRP. Relapses of the symptoms cannot be avoided but might be delayed.

Shykhon M, Kuo M, Pearman K (2002) Recurrent respiratory papillomatosis. Clin Otolaryngol Allied Sci 27(4):237–243PubMedCrossRef

Bernard HU, Burk RD, Chen Z, van Doorslaer K, Hausen H, de Villiers EM (2010) Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401(1):70–79. doi:10.1016/j.virol.2010.02.002 PubMedCrossRef

Bonagura VR, Hatam LJ, Rosenthal DW, de Voti JA, Lam F, Steinberg BM, Abramson AL (2010) Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. APMIS 118(6–7):455–470. doi:10.1111/j.1600-0463.2010.02617.x PubMedCrossRef

Maloney EM, Unger ER, Tucker RA, Swan D, Karem K, Todd NW, Reeves WC (2006) Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 132(7):711–715. doi:10.1001/archotol.132.7.711 PubMedCrossRef

Wiatrak BJ, Wiatrak DW, Broker TR, Lewis L (2004) Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope 114(11 Pt 2 Suppl 104):1–23. doi:10.1097/01.mlg.000148224.83491.0f PubMedCrossRef

Rabah R, Lancaster WD, Thomas R, Gregoire L (2001) Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. Pediatr Dev Pathol 4(1):68–72PubMedCrossRef

Goon P, Sonnex C, Jani P, Stanley M, Sudhoff H (2008) Recurrent respiratory papillomatosis: an overview of current thinking and treatment. Eur Arch Otorhinolaryngol 265(2):147–151. doi:10.1007/s00405-007-0546-z PubMedCrossRef

Mitrani-Rosenbaum S, Tsvieli R, Tur-Kaspa R (1989) Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical carcinoma cells. J Gen Virol 70(Pt 8):2227–2232PubMedCrossRef

Sen GC (1982) Mechanism of interferon action: progress toward its understanding. Prog Nucleic Acid Res Mol Biol 27:105–156PubMedCrossRef

10.

Chadha NK, James AL (2007) Antiviral agents for the treatment of recurrent respiratory papillomatosis: a systematic review of the English-language literature. Otolaryngol Head Neck Surg 136(6):863–869. doi:10.1016/j.otohns.2006.09.007 PubMedCrossRef

11.

Johnson JA, Gangemi JD (1999) Selective inhibition of human papillomavirus-induced cell proliferation by (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Antimicrob Agents Chemother 43(5):1198–1205PubMed

12.

Yang Y, Zhao X, Chen W, Gao Z, Liu A, Guo J, Yan Z, Dou Y, Wang H, Li Y (2010) Effects of cidofovir on human papillomavirus-positive cervical cancer cells xenografts in nude mice. Oncol Res 18(11–12):519–527PubMedCrossRef

13.

Carvalho CM, Huot L, Charlois AL, Khalfallah SA, Chapuis F, Froehlich P (2009) Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patients. Acta Otolaryngol 129(4):462–470. doi:10.1080/00016480902737986 PubMedCrossRef

14.

Chadha NK, James A (2010) Adjuvant antiviral therapy for recurrent respiratory papillomatosis. Cochrane Database Syst Rev (1):CD005053. doi:10.1002/14651858.CD005053.pub3

15.

Donne AJ, Hampson L, He XT, Day PJ, Salway F, Rothera MP, Homer JJ, Hampson IN (2009) Potential risk factors associated with the use of cidofovir to treat benign human papillomavirus-related disease. Antivir Ther 14(7):939–952. doi:10.3851/IMP1421 PubMedCrossRef

16.

Ortiz A, Justo P, Sanz A, Melero R, Caramelo C, Guerrero MF, Strutz F, Muller G, Barat A, Egido J (2005) Tubular cell apoptosis and cidofovir-induced acute renal failure. Antivir Ther 10(1):185–190PubMed

17.

Tjon Pian Gi RE, Dietz A, Djukic V, Eckel HE, Friedrich G, Golusinski W, Hantzakos A, Lawson G, Remacle M, Rihkanen H, Dikkers FG (2011) Treatment of recurrent respiratory papillomatosis and adverse reactions following off-label use of cidofovir (Vistide((R))). Eur Arch Otorhinolaryngol 269(2):361–362. doi:10.1007/s00405-011-1804-7 PubMedCrossRef

18.

Major T, Sziklai I, Czegledy J, Gall T, Gergely L, Szarka K (2008) Follow-up of HPV DNA copy number in cidofovir therapy of recurrent respiratory papillomatosis. Anticancer Res 28(4B):2169–2174PubMed

19.

Derkay CS, Hester RP, Burke B, Carron J, Lawson L (2004) Analysis of a staging assessment system for prediction of surgical interval in recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol 68(12):1493–1498. doi:10.1016/j.ijporl.2004.06.007 PubMedCrossRef

20.

Weissenborn SJ, Wieland U, Junk M, Pfister H (2010) Quantification of beta-human papillomavirus DNA by real-time PCR. Nat Protoc 5(1):1–13. doi:10.1038/nprot.2009.153 PubMedCrossRef

21.

Weissenborn SJ, Funke AM, Hellmich M, Mallmann P, Fuchs PG, Pfister HJ, Wieland U (2003) Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated. J Clin Microbiol 41(6):2763–2767PubMedCrossRef

22.

Wieland U, Jurk S, Weissenborn S, Krieg T, Pfister H, Ritzkowsky A (2000) Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ. J Invest Dermatol 115(3):396–401. doi:10.1046/j.1523-1747.2000.00069.x PubMedCrossRef

23.

McMurray JS, Connor N, Ford CN (2008) Cidofovir efficacy in recurrent respiratory papillomatosis: a randomized, double-blind, placebo-controlled study. Ann Otol Rhinol Laryngol 117(7):477–483PubMed

24.

Mandell DL, Arjmand EM, Kay DJ, Casselbrant ML, Rosen CA (2004) Intralesional cidofovir for pediatric recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 130(11):1319–1323. doi:10.1001/archotol.130.11.1319 PubMedCrossRef

25.

Dikkers FG (2008) Intralesional cidofovir does not increase the risk of laryngeal dysplasia or laryngeal carcinoma. Int J Pediatr Otorhinolaryngol 72(10):1581–1582. doi:10.1016/j.ijporl.2008.05.013 author reply 1583PubMedCrossRef

26.

Soma MA, Albert DM (2008) Cidofovir: to use or not to use? Curr Opin Otolaryngol Head Neck Surg 16(1):86–90. doi:10.1097/MOO.0b013e3282f43408 PubMedCrossRef

27.

Broekema FI, Dikkers FG (2008) Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 265(8):871–879. doi:10.1007/s00405-008-0658-0 PubMedCrossRef

28.

Snoeck R, Wellens W, Desloovere C, Van Ranst M, Naesens L, De Clercq E, Feenstra L (1998) Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]. J Med Virol 54(3):219–225PubMedCrossRef

Title: The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis
Authors: S. Mikolajczak
G. Quante
S. Weissenborn
A. Wafaisade
U. Wieland
J. C. Lüers
J. P. Klussmann
D. Beutner
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 12/2012
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2103-7

At a glance: The STEP trials

Springer Medicine

The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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