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European Archives of Oto-Rhino-Laryngology

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Open Access 01-02-2008 | Review Article

Recurrent respiratory papillomatosis: an overview of current thinking and treatment

Authors: Peter Goon, Chris Sonnex, Piyush Jani, Margaret Stanley, Holger Sudhoff

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2008

Abstract

Human papillomaviruses (HPV) infection in benign laryngeal papillomas is well established. The vast majority of recurrent respiratory papillomatosis lesions are due to HPV types 6 and 11. Human papillomaviruses are small non-enveloped viruses (>8 kb), that replicate within the nuclei of infected host cells. Infected host basal cell keratinocytes and papillomas arise from the disordered proliferation of these differentiating keratinocytes. Surgical debulking of papillomas is currently the treatment of choice; newer surgical approaches utilizing microdebriders are replacing laser ablation. Surgery aims to secure an adequate airway and improve and maintain an acceptable quality of voice. Adjuvant treatments currently used include cidofovir, indole-3-carbinol, ribavirin, mumps vaccine, and photodynamic therapy. The recent licensing of prophylactic HPV vaccines is a most interesting development. The low incidence of RRP does pose significant problems in recruitment of sufficient numbers to show statistical significance. Large multi-centre collaborative clinical trials are therefore required. Even so, sufficient clinical follow-up data would take several years.

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Title: Recurrent respiratory papillomatosis: an overview of current thinking and treatment
Authors: Peter Goon
Chris Sonnex
Piyush Jani
Margaret Stanley
Holger Sudhoff
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2008
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-007-0546-z

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Recurrent respiratory papillomatosis: an overview of current thinking and treatment

Abstract

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Abstract

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