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Published in: European Archives of Oto-Rhino-Laryngology 1/2013

01-01-2013 | Review Article

Sinonasal tumors: a clinicopathologic update of selected tumors

Authors: Pieter J. Slootweg, Alfio Ferlito, Antonio Cardesa, Lester D. R. Thompson, Jennifer L. Hunt, Primož Strojan, Robert P. Takes, Asterios Triantafyllou, Julia A. Woolgar, Alessandra Rinaldo, Kenneth O. Devaney, Leon Barnes

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2013

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Abstract

The sinonasal cavities show a wide variety of neoplasms of epithelial, mesenchymal, neural/neuroectodermal or hematopoietic origin. The differential diagnosis for these tumors may be difficult due to overlapping morphologies, variable patterns in ancillary studies, and potentially confusing terminology. In this report, an updated review of the spectrum of neoplasia is provided, using the World Health Organization 2005 classification as a guide. Classic tumors that are generally limited to the sinonasal tract are described and new information regarding molecular pathogenesis is reviewed. Also new entities that have the sinonasal tract as a site of predilection, such as sinonasal renal cell-like adenocarcinoma and NUT midline carcinoma are highlighted.
Literature
1.
go back to reference Barnes L, Tse LLY, Hunt J (2005) Schneiderian papillomas. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 28–32 Barnes L, Tse LLY, Hunt J (2005) Schneiderian papillomas. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 28–32
2.
go back to reference Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS (2007) Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol 121:857–864PubMedCrossRef Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS (2007) Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol 121:857–864PubMedCrossRef
3.
go back to reference Sandison A (2009) Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol 3:260–262PubMedCrossRef Sandison A (2009) Common head and neck cases in our consultation referrals: diagnostic dilemmas in inverted papilloma. Head Neck Pathol 3:260–262PubMedCrossRef
4.
go back to reference Barnes L (2009) Diseases of the nasal cavity, paranasal sinuses and nasopharynx. In: Barnes L (ed) Surgical pathology of the head and neck. Informa Healthcare, New York, pp 343–422 Barnes L (2009) Diseases of the nasal cavity, paranasal sinuses and nasopharynx. In: Barnes L (ed) Surgical pathology of the head and neck. Informa Healthcare, New York, pp 343–422
5.
go back to reference Altavilla G, Staffieri A, Busatto G, Canesso A, Giacomelli L, Marioni G (2009) Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. Acta Otolaryngol 129:1242–1249PubMedCrossRef Altavilla G, Staffieri A, Busatto G, Canesso A, Giacomelli L, Marioni G (2009) Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. Acta Otolaryngol 129:1242–1249PubMedCrossRef
6.
go back to reference Cheung FM, Lau TW, Cheung LK, Li AS, Chow SK, Lo AW (2010) Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. Ear Nose Throat J 89:E5–E12PubMed Cheung FM, Lau TW, Cheung LK, Li AS, Chow SK, Lo AW (2010) Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. Ear Nose Throat J 89:E5–E12PubMed
7.
go back to reference Kim SG, Lee OY, Choi JW, Park YH, Kim YM, Yeo MK, Kim JM, Rha KS (2010) Pattern of expression of cell cycle-related proteins in malignant transformation of sinonasal inverted papilloma. Am J Rhinol Allergy 25:75–81CrossRef Kim SG, Lee OY, Choi JW, Park YH, Kim YM, Yeo MK, Kim JM, Rha KS (2010) Pattern of expression of cell cycle-related proteins in malignant transformation of sinonasal inverted papilloma. Am J Rhinol Allergy 25:75–81CrossRef
8.
go back to reference Strojan P, Ferlito A, Lund VJ, Kennedy DW, Silver CE, Rinaldo A, Barnes L (2012) Sinonasal inverted papilloma associated with malignancy: the role of human papillomavirus infection and its implications for radiotherapy. Oral Oncol 48:216–218PubMedCrossRef Strojan P, Ferlito A, Lund VJ, Kennedy DW, Silver CE, Rinaldo A, Barnes L (2012) Sinonasal inverted papilloma associated with malignancy: the role of human papillomavirus infection and its implications for radiotherapy. Oral Oncol 48:216–218PubMedCrossRef
9.
go back to reference Jenko K, Kocjan B, Zidar N, Poljak M, Strojan P, Zargi M, Blatnik O, Gale N (2011) In inverted papillomas HPV more likely represents incidental colonization than an etiological factor. Virchows Arch 459:529–538PubMedCrossRef Jenko K, Kocjan B, Zidar N, Poljak M, Strojan P, Zargi M, Blatnik O, Gale N (2011) In inverted papillomas HPV more likely represents incidental colonization than an etiological factor. Virchows Arch 459:529–538PubMedCrossRef
10.
go back to reference Sham CL, To KF, Chan PK, Lee DL, Tong MC, van Hasselt CA (2012) Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients. Head Neck 34:520–533 Sham CL, To KF, Chan PK, Lee DL, Tong MC, van Hasselt CA (2012) Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients. Head Neck 34:520–533
11.
go back to reference Shah AA, Evans MF, Adamson CS, Peng Z, Rajendran V, Cooper K (2010) HPV DNA is associated with a subset of Schneiderian papillomas but does not correlate with p16(INK4a) immunoreactivity. Head Neck Pathol 4:106–112PubMedCrossRef Shah AA, Evans MF, Adamson CS, Peng Z, Rajendran V, Cooper K (2010) HPV DNA is associated with a subset of Schneiderian papillomas but does not correlate with p16(INK4a) immunoreactivity. Head Neck Pathol 4:106–112PubMedCrossRef
12.
go back to reference Perez-Ordoñez B (2009) Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx. J Clin Pathol 62:1085–1095PubMedCrossRef Perez-Ordoñez B (2009) Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx. J Clin Pathol 62:1085–1095PubMedCrossRef
13.
go back to reference Kaufman MR, Brandwein MS, Lawson W (2002) Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas. Laryngoscope 112:1372–1377PubMedCrossRef Kaufman MR, Brandwein MS, Lawson W (2002) Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas. Laryngoscope 112:1372–1377PubMedCrossRef
14.
go back to reference Pilch BZ, Bouquot J, Thompson LDR (2005) Squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 15–17 Pilch BZ, Bouquot J, Thompson LDR (2005) Squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 15–17
15.
go back to reference Cardesa A, Alos L, Franchi A (2006) Nasal cavity and paranasal sinuses. In: Cardesa A, Slootweg PJ (eds) Pathology of the head and neck. Springer, Berlin, pp 50–58CrossRef Cardesa A, Alos L, Franchi A (2006) Nasal cavity and paranasal sinuses. In: Cardesa A, Slootweg PJ (eds) Pathology of the head and neck. Springer, Berlin, pp 50–58CrossRef
16.
go back to reference Ringertz N (1938) Pathology of malignant tumours arising in the nasal and paranasal cavities and maxilla. Acta Otolaryngol Suppl 27:95–157 Ringertz N (1938) Pathology of malignant tumours arising in the nasal and paranasal cavities and maxilla. Acta Otolaryngol Suppl 27:95–157
17.
go back to reference Turner JH, Reh DD (2011) Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck. doi:10.1002/hed.21830 (Epub ahead of print) Turner JH, Reh DD (2011) Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck. doi:10.​1002/​hed.​21830 (Epub ahead of print)
18.
go back to reference El-Mofty SK, Lu DW (2005) Prevalence of high-risk Human Papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract. A distinct clinicopathologic and molecular disease entity. Am J Surg Pathol 29:1367–1372PubMedCrossRef El-Mofty SK, Lu DW (2005) Prevalence of high-risk Human Papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract. A distinct clinicopathologic and molecular disease entity. Am J Surg Pathol 29:1367–1372PubMedCrossRef
19.
go back to reference Alos L, Moyano S, Nadal A, Alobid I, Blanch JL, Ayala E, Lloveras B, Quint W, Cardesa A, Ordi J (2009) Human papilloma viruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome. Cancer 115:2701–2709PubMedCrossRef Alos L, Moyano S, Nadal A, Alobid I, Blanch JL, Ayala E, Lloveras B, Quint W, Cardesa A, Ordi J (2009) Human papilloma viruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome. Cancer 115:2701–2709PubMedCrossRef
20.
go back to reference Ejaz A, Wenig BM (2005) Sinonasal undifferentiated carcinoma. Clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol 12:134–143PubMedCrossRef Ejaz A, Wenig BM (2005) Sinonasal undifferentiated carcinoma. Clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol 12:134–143PubMedCrossRef
21.
go back to reference Wenig BM (2009) Undifferentiated malignant neoplasms of the sinonasal tract. Arch Pathol Lab Med 133:699–712PubMed Wenig BM (2009) Undifferentiated malignant neoplasms of the sinonasal tract. Arch Pathol Lab Med 133:699–712PubMed
22.
go back to reference Franchi A, Palomba A, Cardesa A (2011) Current diagnostic strategies for undifferentiated tumours of the nasal cavities and paranasal sinuses. Histopathology 59:1034–1045PubMedCrossRef Franchi A, Palomba A, Cardesa A (2011) Current diagnostic strategies for undifferentiated tumours of the nasal cavities and paranasal sinuses. Histopathology 59:1034–1045PubMedCrossRef
23.
go back to reference Tanzler ED, Morris CG, Orlando CA, Werning JW, Mendenhall WM (2008) Management of sinonasal undifferentiated carcinoma. Head Neck 30:595–599PubMedCrossRef Tanzler ED, Morris CG, Orlando CA, Werning JW, Mendenhall WM (2008) Management of sinonasal undifferentiated carcinoma. Head Neck 30:595–599PubMedCrossRef
24.
go back to reference Rischin D, Porceddu S, Peters L, Martin J, Corry J, Weih L (2004) Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck 26:435–441PubMedCrossRef Rischin D, Porceddu S, Peters L, Martin J, Corry J, Weih L (2004) Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck 26:435–441PubMedCrossRef
27.
go back to reference Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA (2009) Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol 33:984–991PubMedCrossRef Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA (2009) Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol 33:984–991PubMedCrossRef
28.
go back to reference Frierson HF, Franchi A, Santucci M, Wenig BM (2005) Adenocarcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 20–23 Frierson HF, Franchi A, Santucci M, Wenig BM (2005) Adenocarcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 20–23
29.
go back to reference Stelow EB, Mills SE, Jo VY, Carlson DL (2010) Adenocarcinoma of the upper aerodigestive tract. Adv Anat Pathol 17:262–269PubMedCrossRef Stelow EB, Mills SE, Jo VY, Carlson DL (2010) Adenocarcinoma of the upper aerodigestive tract. Adv Anat Pathol 17:262–269PubMedCrossRef
30.
go back to reference Martínez JG, Pérez-Escuredo J, López F, Suárez C, Alvarez-Marcos C, Llorente JL, Hermsen MA (2009) Microsatellite instability analysis of sinonasal carcinomas. Otolaryngol Head Neck Surg 140:55–60PubMedCrossRef Martínez JG, Pérez-Escuredo J, López F, Suárez C, Alvarez-Marcos C, Llorente JL, Hermsen MA (2009) Microsatellite instability analysis of sinonasal carcinomas. Otolaryngol Head Neck Surg 140:55–60PubMedCrossRef
31.
go back to reference Hermsen MA, Llorente JL, Pérez-Escuredo J, López F, Ylstra B, Alvarez-Marcos C, Suárez C (2009) Genome-wide analysis of genetic changes in intestinal-type sinonasal adenocarcinoma. Head Neck 31:290–297PubMedCrossRef Hermsen MA, Llorente JL, Pérez-Escuredo J, López F, Ylstra B, Alvarez-Marcos C, Suárez C (2009) Genome-wide analysis of genetic changes in intestinal-type sinonasal adenocarcinoma. Head Neck 31:290–297PubMedCrossRef
32.
go back to reference Saber AT, Nielsen LR, Dictor M, Hagmar L, Mikoczy Z, Wallin H (1998) K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust. Cancer Lett 126:59–65PubMedCrossRef Saber AT, Nielsen LR, Dictor M, Hagmar L, Mikoczy Z, Wallin H (1998) K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust. Cancer Lett 126:59–65PubMedCrossRef
33.
go back to reference Tripodi D, Ferron C, Malard O, de Montreuil CB, Planche L, Sebille-Rivain V, Roedlich C, Quéméner S, Renaudin K, Longuenesse C, Verger C, Meflah K, Gratas C, Géraut C (2011) Relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma. Laryngoscope 121:2011–2018PubMed Tripodi D, Ferron C, Malard O, de Montreuil CB, Planche L, Sebille-Rivain V, Roedlich C, Quéméner S, Renaudin K, Longuenesse C, Verger C, Meflah K, Gratas C, Géraut C (2011) Relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma. Laryngoscope 121:2011–2018PubMed
34.
go back to reference Skalova A, Cardesa A, Leivo I, Pfaltz M, Ryska A, Simpson R, Michal M (2003) Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of a poorly recognized entity. Virchows Arch 443:152–158PubMedCrossRef Skalova A, Cardesa A, Leivo I, Pfaltz M, Ryska A, Simpson R, Michal M (2003) Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of a poorly recognized entity. Virchows Arch 443:152–158PubMedCrossRef
35.
go back to reference Jo VY, Mills SE, Cathro HP, Carlson DL, Stelow EB (2009) Low-grade sinonasal adenocarcinomas: the association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions. Am J Surg Pathol 33:401–408PubMedCrossRef Jo VY, Mills SE, Cathro HP, Carlson DL, Stelow EB (2009) Low-grade sinonasal adenocarcinomas: the association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions. Am J Surg Pathol 33:401–408PubMedCrossRef
36.
go back to reference Zur KB, Brandwein M, Wang B, Som P, Gordon R, Urken ML (2002) Primary description of a new entity. Renal cell–like carcinoma of the nasal cavity: van Meegeren in the house of Vermeer. Arch Otolaryngol Head Neck Surg 128:441–447PubMed Zur KB, Brandwein M, Wang B, Som P, Gordon R, Urken ML (2002) Primary description of a new entity. Renal cell–like carcinoma of the nasal cavity: van Meegeren in the house of Vermeer. Arch Otolaryngol Head Neck Surg 128:441–447PubMed
37.
go back to reference Storck K, Hadi UM, Simpson R, Ramer M, Brandwein-Gensler M (2008) Sinonasal renal cell-like adenocarcinoma: a report on four patients. Head Neck Pathol 2:75–80PubMedCrossRef Storck K, Hadi UM, Simpson R, Ramer M, Brandwein-Gensler M (2008) Sinonasal renal cell-like adenocarcinoma: a report on four patients. Head Neck Pathol 2:75–80PubMedCrossRef
38.
go back to reference Perez-Ordoñez B (2005) Neuroendocrine carcinomas. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 26–27 Perez-Ordoñez B (2005) Neuroendocrine carcinomas. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 26–27
39.
go back to reference Weng CT, Chu PY, Liu MT, Chen MK (2008) Small cell carcinoma of the head and neck: a single institution’s experience and review of the literature. J Otolaryngol Head Neck Surg 37:788–793PubMed Weng CT, Chu PY, Liu MT, Chen MK (2008) Small cell carcinoma of the head and neck: a single institution’s experience and review of the literature. J Otolaryngol Head Neck Surg 37:788–793PubMed
40.
go back to reference Rosenthal DI, Barker JL Jr, El-Naggar AK, Glisson BS, Kies MS, Diaz EM Jr, Clayman GL, Demonte F, Selek U, Morrison WH, Ang KK, Chao KS, Garden AS (2004) Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer 101:2567–2573PubMedCrossRef Rosenthal DI, Barker JL Jr, El-Naggar AK, Glisson BS, Kies MS, Diaz EM Jr, Clayman GL, Demonte F, Selek U, Morrison WH, Ang KK, Chao KS, Garden AS (2004) Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer 101:2567–2573PubMedCrossRef
41.
go back to reference Babin E, Rouleau V, Vedrine PO, Toussaint B, de Raucourt D, Malard O, Cosmidis A, Makaeieff M, Dehesdin D (2006) Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. J Laryngol Otol 120:289–297PubMedCrossRef Babin E, Rouleau V, Vedrine PO, Toussaint B, de Raucourt D, Malard O, Cosmidis A, Makaeieff M, Dehesdin D (2006) Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. J Laryngol Otol 120:289–297PubMedCrossRef
43.
go back to reference Wooff JC, Weinreb I, Perez-Ordonez B, Magee JF, Bullock MJ (2011) Calretinin staining facilitates differentiation of olfactory neuroblastoma from other small round blue cell tumors in the sinonasal tract. Am J Surg Pathol 35:1786–1793PubMedCrossRef Wooff JC, Weinreb I, Perez-Ordonez B, Magee JF, Bullock MJ (2011) Calretinin staining facilitates differentiation of olfactory neuroblastoma from other small round blue cell tumors in the sinonasal tract. Am J Surg Pathol 35:1786–1793PubMedCrossRef
44.
go back to reference Guled M, Myllykangas S, Frierson HF Jr, Mills SE, Knuutila S, Stelow EB (2008) Array comparative genomic hybridization analysis of olfactory neuroblastoma. Mod Pathol 21:770–778PubMedCrossRef Guled M, Myllykangas S, Frierson HF Jr, Mills SE, Knuutila S, Stelow EB (2008) Array comparative genomic hybridization analysis of olfactory neuroblastoma. Mod Pathol 21:770–778PubMedCrossRef
45.
go back to reference Kadish S, Goodman M, Wang CC (1976) Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 37:1571–1576PubMedCrossRef Kadish S, Goodman M, Wang CC (1976) Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 37:1571–1576PubMedCrossRef
46.
go back to reference Smee RI, Broadley K, Williams JR, Meagher NS, Bridger GP (2011) Retained role of surgery for olfactory neuroblastoma. Head Neck 33:1486–1492PubMedCrossRef Smee RI, Broadley K, Williams JR, Meagher NS, Bridger GP (2011) Retained role of surgery for olfactory neuroblastoma. Head Neck 33:1486–1492PubMedCrossRef
47.
go back to reference Zanation AM, Ferlito A, Rinaldo A, Gore MR, Lund VJ, McKinney KA, Suárez C, Takes RP, Devaiah AK (2010) When, how and why to treat the neck in patients with esthesioneuroblastoma: a review. Eur Arch Otorhinolaryngol 267:1667–1671PubMedCrossRef Zanation AM, Ferlito A, Rinaldo A, Gore MR, Lund VJ, McKinney KA, Suárez C, Takes RP, Devaiah AK (2010) When, how and why to treat the neck in patients with esthesioneuroblastoma: a review. Eur Arch Otorhinolaryngol 267:1667–1671PubMedCrossRef
48.
go back to reference Wenig BM, Dulguerov P, Kapadia SB, Prasad ML, Fanburg-Smith JC, Thompson LDR (2005) Neuroectodermal tumours. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 65–75 Wenig BM, Dulguerov P, Kapadia SB, Prasad ML, Fanburg-Smith JC, Thompson LDR (2005) Neuroectodermal tumours. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 65–75
49.
go back to reference Thompson LD, Wieneke JA, Miettinen M (2003) Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 27:594–611PubMedCrossRef Thompson LD, Wieneke JA, Miettinen M (2003) Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 27:594–611PubMedCrossRef
50.
go back to reference Cohen Y, Rosenbaum E, Begum S, Goldenberg D, Esche C, Lavie O, Sidransky D, Westra WH (2004) Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites. Clin Cancer Res 10:3444–3447PubMedCrossRef Cohen Y, Rosenbaum E, Begum S, Goldenberg D, Esche C, Lavie O, Sidransky D, Westra WH (2004) Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites. Clin Cancer Res 10:3444–3447PubMedCrossRef
51.
go back to reference Yun J, Lee J, Jang J, Lee EJ, Jang KT, Kim JH, Kim KM (2011) KIT amplification and gene mutations in acral/mucosal melanoma in Korea. APMIS 119:330–335PubMedCrossRef Yun J, Lee J, Jang J, Lee EJ, Jang KT, Kim JH, Kim KM (2011) KIT amplification and gene mutations in acral/mucosal melanoma in Korea. APMIS 119:330–335PubMedCrossRef
52.
go back to reference Beadling C, Jacobson-Dunlop E, Hodi FS, Le C, Warrick A, Patterson J, Town A, Harlow A, Cruz F 3rd, Azar S, Rubin BP, Muller S, West R, Heinrich MC, Corless CL (2008) KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 14:6821–6828PubMedCrossRef Beadling C, Jacobson-Dunlop E, Hodi FS, Le C, Warrick A, Patterson J, Town A, Harlow A, Cruz F 3rd, Azar S, Rubin BP, Muller S, West R, Heinrich MC, Corless CL (2008) KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 14:6821–6828PubMedCrossRef
53.
go back to reference Papaspyrou G, Garbe C, Schadendorf D, Werner JA, Hauschild A, Egberts F (2011) Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res 21:475–482PubMedCrossRef Papaspyrou G, Garbe C, Schadendorf D, Werner JA, Hauschild A, Egberts F (2011) Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res 21:475–482PubMedCrossRef
54.
go back to reference Franchi A, Alos L, Gale N, Massi D, Paglierani M, Santucci M, Zidar N, Cardesa A (2006) Expression of p16 in sinonasal malignant melanoma. Virchows Arch 449:667–672PubMedCrossRef Franchi A, Alos L, Gale N, Massi D, Paglierani M, Santucci M, Zidar N, Cardesa A (2006) Expression of p16 in sinonasal malignant melanoma. Virchows Arch 449:667–672PubMedCrossRef
55.
go back to reference Gal TJ, Silver N, Huang B (2011) Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 121:2026–2033PubMed Gal TJ, Silver N, Huang B (2011) Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 121:2026–2033PubMed
56.
go back to reference Rinaldo A, Shaha AR, Patel SG, Ferlito A (2001) Primary mucosal melanoma of the nasal cavity and paranasal sinuses. Acta Otolaryngol 121:979–982PubMedCrossRef Rinaldo A, Shaha AR, Patel SG, Ferlito A (2001) Primary mucosal melanoma of the nasal cavity and paranasal sinuses. Acta Otolaryngol 121:979–982PubMedCrossRef
57.
go back to reference Krengli M, Jereczek-Fossa BA, Kaanders JHAM, Masini L, Beldì D, Orecchia R (2008) What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit Rev Oncol Hematol 65:121–128PubMedCrossRef Krengli M, Jereczek-Fossa BA, Kaanders JHAM, Masini L, Beldì D, Orecchia R (2008) What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit Rev Oncol Hematol 65:121–128PubMedCrossRef
58.
go back to reference Thompson LD, Miettinen M, Wenig BM (2003) Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol 27:737–749PubMedCrossRef Thompson LD, Miettinen M, Wenig BM (2003) Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol 27:737–749PubMedCrossRef
59.
go back to reference Dandekar M, McHugh JB (2010) Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis. Arch Pathol Lab Med 134:1444–1449PubMed Dandekar M, McHugh JB (2010) Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis. Arch Pathol Lab Med 134:1444–1449PubMed
60.
go back to reference Higashi K, Nakaya K, Watanabe M, Ikeda R, Suzuki T, Oshima T, Kobayashi T (2011) Glomangiopericytoma of the nasal cavity. Auris Nasus Larynx 38:415–417PubMedCrossRef Higashi K, Nakaya K, Watanabe M, Ikeda R, Suzuki T, Oshima T, Kobayashi T (2011) Glomangiopericytoma of the nasal cavity. Auris Nasus Larynx 38:415–417PubMedCrossRef
61.
go back to reference Campo E, Cardesa A, Alos L, Palacin A, Cobarro J, Traserra J, Montserrat E (1991) Non-Hodgkin’s lymphomas of nasal cavity and paranasal sinuses. An immunohistochemical study. Am J Clin Pathol 96:184–190PubMed Campo E, Cardesa A, Alos L, Palacin A, Cobarro J, Traserra J, Montserrat E (1991) Non-Hodgkin’s lymphomas of nasal cavity and paranasal sinuses. An immunohistochemical study. Am J Clin Pathol 96:184–190PubMed
62.
go back to reference Vega F, Lin P, Medeiros LJ (2005) Extranodal lymphomas of the head and neck. Ann Diagn Pathol 9:340–350PubMedCrossRef Vega F, Lin P, Medeiros LJ (2005) Extranodal lymphomas of the head and neck. Ann Diagn Pathol 9:340–350PubMedCrossRef
63.
go back to reference Carbone A, Gloghini A, Rinaldo A, Devaney KO, Tubbs R, Ferlito A (2009) True identity by immunohistochemistry and molecular morphology of undifferentiated malignancies of the head and neck. Head Neck 31:949–961PubMedCrossRef Carbone A, Gloghini A, Rinaldo A, Devaney KO, Tubbs R, Ferlito A (2009) True identity by immunohistochemistry and molecular morphology of undifferentiated malignancies of the head and neck. Head Neck 31:949–961PubMedCrossRef
64.
go back to reference Chan JKC, Jaffe ES, Ralfkiaer E (2001) Extranodal NK/T cell lymphoma, nasal type. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of haemopoietic and lymphoid tissues. IARC press, Lyon, pp 204–207 Chan JKC, Jaffe ES, Ralfkiaer E (2001) Extranodal NK/T cell lymphoma, nasal type. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of haemopoietic and lymphoid tissues. IARC press, Lyon, pp 204–207
65.
go back to reference Rodrigo JP, Suárez C, Rinaldo A, Devaney KO, Carbone A, Barnes L, Heffner DK, Ferlito A (2005) Idiopathic midline destructive disease: fact or fiction. Oral Oncol 41:340–348PubMedCrossRef Rodrigo JP, Suárez C, Rinaldo A, Devaney KO, Carbone A, Barnes L, Heffner DK, Ferlito A (2005) Idiopathic midline destructive disease: fact or fiction. Oral Oncol 41:340–348PubMedCrossRef
66.
go back to reference Li CC, Tien HF, Tang JL, Yao M, Chen YC, Su IJ, Hsu SM, Hong RL (2004) Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma. Cancer 100:366–375PubMedCrossRef Li CC, Tien HF, Tang JL, Yao M, Chen YC, Su IJ, Hsu SM, Hong RL (2004) Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma. Cancer 100:366–375PubMedCrossRef
67.
go back to reference Li YX, Yao B, Jin J, Wang WH, Liu YP, Song YW, Wang SL, Liu XF, Zhou LQ, He XH, Lu N, Yu ZH (2006) Radiotherapy as primary treatment for stage IE and IIE nasal natural killer/T-cell lymphoma. J Clin Oncol 24:181–189PubMedCrossRef Li YX, Yao B, Jin J, Wang WH, Liu YP, Song YW, Wang SL, Liu XF, Zhou LQ, He XH, Lu N, Yu ZH (2006) Radiotherapy as primary treatment for stage IE and IIE nasal natural killer/T-cell lymphoma. J Clin Oncol 24:181–189PubMedCrossRef
68.
go back to reference Gou Y, Lu JJ, Ma X, Wang B, Hong X, Li X, Li J (2008) Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy. Oral Oncol 44:23–30CrossRef Gou Y, Lu JJ, Ma X, Wang B, Hong X, Li X, Li J (2008) Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy. Oral Oncol 44:23–30CrossRef
69.
go back to reference Lin TC, Chen SU, Chen YF, Chang YC, Lin CW (2012) Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion. Histopathology 60:287–295PubMedCrossRef Lin TC, Chen SU, Chen YF, Chang YC, Lin CW (2012) Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion. Histopathology 60:287–295PubMedCrossRef
70.
go back to reference Shanmugaratnam K, Kunaratnam N, Chia KB, Chiang GSC, Sinniah R (1983) Teratoid carcinosarcoma of the paranasal sinuses. Pathology 15:413–419PubMedCrossRef Shanmugaratnam K, Kunaratnam N, Chia KB, Chiang GSC, Sinniah R (1983) Teratoid carcinosarcoma of the paranasal sinuses. Pathology 15:413–419PubMedCrossRef
71.
go back to reference Heffner DK, Hyams VJ (1984) Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses. A clinicopathologic study of 20 cases. Cancer 53:2140–2154 Heffner DK, Hyams VJ (1984) Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses. A clinicopathologic study of 20 cases. Cancer 53:2140–2154
72.
go back to reference Cardesa A, Luna MA (2005) Germ cell tumours. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 76–79 Cardesa A, Luna MA (2005) Germ cell tumours. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC press, Lyon, pp 76–79
73.
go back to reference Pai SA, Naresh KN, Masih K, Ramarao C, Borges AM (1998) Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study. Hum Pathol 29:718–722PubMedCrossRef Pai SA, Naresh KN, Masih K, Ramarao C, Borges AM (1998) Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study. Hum Pathol 29:718–722PubMedCrossRef
74.
go back to reference Fernández PL, Cardesa A, Alós L, Pinto J, Traserra J (1995) Sinonasal teratocarcinosarcoma: an unusual neoplasm. Pathol Res Pract 191:166–171PubMedCrossRef Fernández PL, Cardesa A, Alós L, Pinto J, Traserra J (1995) Sinonasal teratocarcinosarcoma: an unusual neoplasm. Pathol Res Pract 191:166–171PubMedCrossRef
75.
go back to reference Shemen L, Galantich P, Murali R (1995) Malignant teratocarcinosarcoma of sphenoid sinus. Otolaryngol Head Neck Surg 112:496–500PubMedCrossRef Shemen L, Galantich P, Murali R (1995) Malignant teratocarcinosarcoma of sphenoid sinus. Otolaryngol Head Neck Surg 112:496–500PubMedCrossRef
76.
go back to reference Carrizo F, Pineda-Daboin K, Neto AG, Luna MA (2006) Pharyngeal teratocarcinosarcoma: review of the literature and report of two cases. Ann Diagn Pathol 10:339–342PubMedCrossRef Carrizo F, Pineda-Daboin K, Neto AG, Luna MA (2006) Pharyngeal teratocarcinosarcoma: review of the literature and report of two cases. Ann Diagn Pathol 10:339–342PubMedCrossRef
77.
go back to reference Vranic S, Caughron SK, Djuricic S, Bilalovic N, Zaman S, Suljevic I, Lydiatt WM, Emanuel J, Gatalica Z (2008) Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: report of three new cases with clinico-pathologic correlation, cytogenetic analysis and review of the literature. BMC Ear Nose Throat Disord 8:8PubMedCrossRef Vranic S, Caughron SK, Djuricic S, Bilalovic N, Zaman S, Suljevic I, Lydiatt WM, Emanuel J, Gatalica Z (2008) Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: report of three new cases with clinico-pathologic correlation, cytogenetic analysis and review of the literature. BMC Ear Nose Throat Disord 8:8PubMedCrossRef
78.
go back to reference Smith SL, Hessel AC, Luna MA, Malpica A, Rosenthal DI, El-Naggar AK (2008) Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients treated at a single institution and comparison with reported series. Arch Otolaryngol Head Neck Surg 134:592–595PubMedCrossRef Smith SL, Hessel AC, Luna MA, Malpica A, Rosenthal DI, El-Naggar AK (2008) Sinonasal teratocarcinosarcoma of the head and neck: a report of 10 patients treated at a single institution and comparison with reported series. Arch Otolaryngol Head Neck Surg 134:592–595PubMedCrossRef
79.
go back to reference Kane SV, Karpate AA, Bal M, Juvekar SL, Pai PS (2009) Chemotherapy-induced neuronal maturation in sinonasal teratocarcinosarcoma—a unique observation. Head Neck Pathol 3:31–36PubMedCrossRef Kane SV, Karpate AA, Bal M, Juvekar SL, Pai PS (2009) Chemotherapy-induced neuronal maturation in sinonasal teratocarcinosarcoma—a unique observation. Head Neck Pathol 3:31–36PubMedCrossRef
Metadata
Title
Sinonasal tumors: a clinicopathologic update of selected tumors
Authors
Pieter J. Slootweg
Alfio Ferlito
Antonio Cardesa
Lester D. R. Thompson
Jennifer L. Hunt
Primož Strojan
Robert P. Takes
Asterios Triantafyllou
Julia A. Woolgar
Alessandra Rinaldo
Kenneth O. Devaney
Leon Barnes
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 1/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-012-2025-4

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