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Published in: European Archives of Oto-Rhino-Laryngology 11/2009

01-11-2009 | Rhinology

Influences of olfactory impairment on depression, cognitive performance, and quality of life in Korean elderly

Authors: Han-Seok Seo, Kwang Jin Jeon, Thomas Hummel, Byung-Chan Min

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2009

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Abstract

Despite high prevalence of olfactory loss in the elderly, this is typically overlooked. The aim of this study was to examine the impact of olfactory loss on depression, cognitive performance, and quality of life (QoL) in the general population of South Korea, and also to investigate the association between the above variables. A total of 127 Korean elderly aged from 65 to 89 years participated in this study. Olfactory sensitivity, depression, cognitive performance, and QoL were assessed with T&T olfactometry, the Geriatric Depression Scale, Mini-Mental State Examination, and a questionnaire for Geriatric Quality of Life, respectively. Subjects with severely impaired olfactory function showed a significantly higher degree of depression, lower cognitive performance, and decreased QoL compared to subjects with normal to moderately impaired olfaction. However, when controlling for cognitive performance, the olfactory sensitivity was not correlated with degrees of depression and QoL. In conclusion, our findings confirm the relationships of olfactory loss with depression, cognitive performance, and QoL; they also indicate that tests of olfactory function could be used in the screening for cognitive impairment.
Literature
5.
go back to reference Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243. doi:10.1007/s00405-006-0173-0 PubMedCrossRef Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243. doi:10.​1007/​s00405-006-0173-0 PubMedCrossRef
10.
go back to reference Laska M, Freist P, Krause S (2007) Which senses play a role in nonhuman primate food selection? A comparison between squirrel monkeys and spider monkeys. Am J Primatol 69:282–294. doi:10.1002/ajp.20345 PubMedCrossRef Laska M, Freist P, Krause S (2007) Which senses play a role in nonhuman primate food selection? A comparison between squirrel monkeys and spider monkeys. Am J Primatol 69:282–294. doi:10.​1002/​ajp.​20345 PubMedCrossRef
13.
15.
go back to reference Pentzek M, Grass-Kapanke B, Ihl R (2007) Odor identification in Alzheimer’s disease and depression. Aging Clin Exp Res 19:255–258PubMed Pentzek M, Grass-Kapanke B, Ihl R (2007) Odor identification in Alzheimer’s disease and depression. Aging Clin Exp Res 19:255–258PubMed
17.
go back to reference Serby M, Corwin J, Conrad P, Rotrosen J (1985) Olfactory dysfunction in Alzheimer’s disease and Parkinson’s disease. Am J Psychiatry 142:781–782PubMed Serby M, Corwin J, Conrad P, Rotrosen J (1985) Olfactory dysfunction in Alzheimer’s disease and Parkinson’s disease. Am J Psychiatry 142:781–782PubMed
18.
go back to reference Suzuki Y, Yamamoto S, Umegaki H, Onishi J, Mogi N, Fujishiro H, Iguchi A (2004) Smell identification test as an indicator for cognitive impairment in Alzheimer’s disease. Int J Geriatr Psychiatry 19:727–733. doi:10.1002/gps.1161 PubMedCrossRef Suzuki Y, Yamamoto S, Umegaki H, Onishi J, Mogi N, Fujishiro H, Iguchi A (2004) Smell identification test as an indicator for cognitive impairment in Alzheimer’s disease. Int J Geriatr Psychiatry 19:727–733. doi:10.​1002/​gps.​1161 PubMedCrossRef
19.
20.
go back to reference Peters JM, Hummel T, Kratzsch T, Lötsch J, Skarke C, Frölich L (2003) Olfactory function in mild cognitive impairment and Alzheimer’s disease: an investigation using psychophysical and electrophysiological techniques. Am J Psychiatry 160:1995–2002. doi:10.1176/appi.ajp.160.11.1995 PubMedCrossRef Peters JM, Hummel T, Kratzsch T, Lötsch J, Skarke C, Frölich L (2003) Olfactory function in mild cognitive impairment and Alzheimer’s disease: an investigation using psychophysical and electrophysiological techniques. Am J Psychiatry 160:1995–2002. doi:10.​1176/​appi.​ajp.​160.​11.​1995 PubMedCrossRef
21.
go back to reference Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER (2001) Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg 127:497–503PubMed Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER (2001) Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg 127:497–503PubMed
24.
go back to reference Shim EJ, Mehnert A, Koyama A, Cho SJ, Inui H, Paik NS, Koch U (2006) Health-related quality of life in breast cancer: a cross-cultural survey of German, Japanese, and South Korean patients. Breast Cancer Res Treat 99:341–350. doi:10.1007/s10549-006-9216-x PubMedCrossRef Shim EJ, Mehnert A, Koyama A, Cho SJ, Inui H, Paik NS, Koch U (2006) Health-related quality of life in breast cancer: a cross-cultural survey of German, Japanese, and South Korean patients. Breast Cancer Res Treat 99:341–350. doi:10.​1007/​s10549-006-9216-x PubMedCrossRef
26.
go back to reference Kee BS, Lee CW (1995) A preliminary study for the standardization of geriatric depression scale in Korea. J Korean Neuropsychiatr Assoc 34:1875–1885 Kee BS, Lee CW (1995) A preliminary study for the standardization of geriatric depression scale in Korea. J Korean Neuropsychiatr Assoc 34:1875–1885
27.
28.
go back to reference Kwon YC, Park JH (1989) Korean version of Mini-Mental State Examination (MMSE-K). Part I. Development of the test for the elderly. J Korean Neuropsychiatr Assoc 28:125–135 Kwon YC, Park JH (1989) Korean version of Mini-Mental State Examination (MMSE-K). Part I. Development of the test for the elderly. J Korean Neuropsychiatr Assoc 28:125–135
30.
go back to reference Park JH, Kwon YC (1989) Standardization of Korean version of the Mini-Mental State Examination (MMSE-K) for use in the elderly. Part II. Diagnostic validity. J Korean Neuropsychiatr Assoc 28:508–513 Park JH, Kwon YC (1989) Standardization of Korean version of the Mini-Mental State Examination (MMSE-K) for use in the elderly. Part II. Diagnostic validity. J Korean Neuropsychiatr Assoc 28:508–513
31.
go back to reference Lee HS, Kim DG, Ko HJ, Gu HM, Kwon UJ, Kim JH (2003) The standardization of Geriatric quality of Life scale. Korean J Clin Psychol 22:859–881 Lee HS, Kim DG, Ko HJ, Gu HM, Kwon UJ, Kim JH (2003) The standardization of Geriatric quality of Life scale. Korean J Clin Psychol 22:859–881
33.
35.
go back to reference Gudziol V, Wolff-Stephan S, Aschenbrenner K, Joraschky P, Hummel T (2009) Depression resulting from olfactory dysfunction is associated with reduced sexual appetite—a cross-sectional cohort study. J Sex Med (in press) Gudziol V, Wolff-Stephan S, Aschenbrenner K, Joraschky P, Hummel T (2009) Depression resulting from olfactory dysfunction is associated with reduced sexual appetite—a cross-sectional cohort study. J Sex Med (in press)
Metadata
Title
Influences of olfactory impairment on depression, cognitive performance, and quality of life in Korean elderly
Authors
Han-Seok Seo
Kwang Jin Jeon
Thomas Hummel
Byung-Chan Min
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 11/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-009-1001-0

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