Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 3/2005

01-03-2005 | Rhinology

Olfactory dysfunction and daily life

Authors: Johannes Frasnelli, Thomas Hummel

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2005

Login to get access

Abstract

The objective of the present study was to investigate the hypothesis that subjects with parosmia suffer more in their daily life than patients who experience only quantitative olfactory loss. Two hundred five outpatients of the Smell and Taste Clinic and 25 healthy controls were included. The newly developed Questionnaire of Olfactory Disorders (QOD) was administered in combination with other psychometric tests (Beck Depression Inventory, “Befindlichkeitsskala” and the Short Form-36 Health Survey) along with an olfactory test (“Sniffin’ Sticks”). Results of the QOD were found to be an appropriate and valid measure of the impact of olfactory dysfunction on daily life. Patients with parosmia and quantitative olfactory dysfunction show higher rates of daily life complaints when compared to patients suffering from quantitative olfactory impairment only (QOD-PS: P=0.005). In addition, hyposmic and anosmic patients indicated significantly more complaints compared to patients with normosmia. Further, female patients seemed to suffer more from olfactory dysfunction than male patients. In conclusion, the assessment of the degree of qualitative olfactory dysfunction may be possible by the use of instruments based on questionnaires regarding daily life problems.
Literature
1.
go back to reference Cain WS, Gent JF, Goodspeed RB, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center (CCCRC). Laryngoscope 98:83–88 Cain WS, Gent JF, Goodspeed RB, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center (CCCRC). Laryngoscope 98:83–88
2.
go back to reference Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, Kimmelman CP, Brightman VJ, Snow JB (1991) Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117:519–528 Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, Kimmelman CP, Brightman VJ, Snow JB (1991) Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117:519–528
3.
go back to reference Doty RL (1986) Gender and endocrine-related influences upon olfactory sensitivity. In: Meiselman H, Rivlin RS (eds) Clinical measurement of taste and smell. MacMillan, New York, pp 377–413 Doty RL (1986) Gender and endocrine-related influences upon olfactory sensitivity. In: Meiselman H, Rivlin RS (eds) Clinical measurement of taste and smell. MacMillan, New York, pp 377–413
4.
go back to reference Doty RL, Genow A, Hummel T (1998) Scratch density differentiates microsmic from normosmic and anosmic subjects on the University of Pennsylvania Smell Identification Test. Percept Mot Skills 86:211–216 Doty RL, Genow A, Hummel T (1998) Scratch density differentiates microsmic from normosmic and anosmic subjects on the University of Pennsylvania Smell Identification Test. Percept Mot Skills 86:211–216
5.
go back to reference Doty RL, Shaman P, Dann M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function (UPSIT). Physiol Behav 32:489–502 Doty RL, Shaman P, Dann M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function (UPSIT). Physiol Behav 32:489–502
6.
go back to reference Duncan HJ, Smith DV (1995) Clinical disorders of olfaction. In: Doty RL (ed) Handbook of olfaction and gustation. Marcel Dekker, New York, pp 345–365 Duncan HJ, Smith DV (1995) Clinical disorders of olfaction. In: Doty RL (ed) Handbook of olfaction and gustation. Marcel Dekker, New York, pp 345–365
7.
go back to reference Eggert D, Ratschinski G (1983) Eysenck-Persönlichkeits-Inventar (EPI). Hogrefe, Göttingen Eggert D, Ratschinski G (1983) Eysenck-Persönlichkeits-Inventar (EPI). Hogrefe, Göttingen
8.
go back to reference Faulcon P, Portier F, Biacabe B, Bonfils P (1999) Anosmie secondaire á une rhinite aiguë: sémiologie et évolution á propos d’une série de 118 patients. Ann Otolaryngol Chir Cervicofac 116:351–357 Faulcon P, Portier F, Biacabe B, Bonfils P (1999) Anosmie secondaire á une rhinite aiguë: sémiologie et évolution á propos d’une série de 118 patients. Ann Otolaryngol Chir Cervicofac 116:351–357
9.
go back to reference Frasnelli JA, Temmel AF, Quint C, Oberbauer R, Hummel T (2002) Olfactory function in chronic renal failure. Am J Rhinol 16:275–279 Frasnelli JA, Temmel AF, Quint C, Oberbauer R, Hummel T (2002) Olfactory function in chronic renal failure. Am J Rhinol 16:275–279
10.
go back to reference Goebel G, Hiller W (1994) Tinnitus-Fragebogen (TF). HNO 42:166–172 Goebel G, Hiller W (1994) Tinnitus-Fragebogen (TF). HNO 42:166–172
11.
go back to reference Hautzinger M, Bailer M, Worall H, Keller F (1995) Beck-Depressions-Inventar (BDI). Hogrefe, Göttingen Hautzinger M, Bailer M, Worall H, Keller F (1995) Beck-Depressions-Inventar (BDI). Hogrefe, Göttingen
12.
go back to reference Hiller W, Goebel G (1992) A psychometric study of complaints in chronic tinnitus. J Psychosom Res 36:337–348 Hiller W, Goebel G (1992) A psychometric study of complaints in chronic tinnitus. J Psychosom Res 36:337–348
13.
go back to reference Hummel T, Heilmann S, Hüttenbrink KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112:2076–2080 Hummel T, Heilmann S, Hüttenbrink KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112:2076–2080
14.
go back to reference Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) “Sniffin’ sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52 Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) “Sniffin’ sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52
15.
go back to reference Kobal G, Hummel T (1998) Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108:1033–1035 Kobal G, Hummel T (1998) Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108:1033–1035
16.
go back to reference Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, Seeber H, Pauli E, Hummel T (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257:205–211 Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, Seeber H, Pauli E, Hummel T (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257:205–211
17.
go back to reference Landis BN, Hummel T, Hugentobler M, Giger R, Lacroix JS (2003) Ratings of overall olfactory function. Chem Senses 28:691–694 Landis BN, Hummel T, Hugentobler M, Giger R, Lacroix JS (2003) Ratings of overall olfactory function. Chem Senses 28:691–694
18.
go back to reference Leopold D (2002) Distortion of olfactory perception: diagnosis and treatment. Chem Senses 27:611–615 Leopold D (2002) Distortion of olfactory perception: diagnosis and treatment. Chem Senses 27:611–615
19.
go back to reference Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER (2001) Impact of olfactory impairment on quality of life and disability. Arch Otorhinolaryngol Head Neck Surg 127:497–503 Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER (2001) Impact of olfactory impairment on quality of life and disability. Arch Otorhinolaryngol Head Neck Surg 127:497–503
20.
go back to reference Nordin S, Monsch AU, Murphy C (1995) Unawareness of smell loss in normal aging and Alzheimer’s disease: discrepancy between self-reported and diagnosed smell sensitivity. J Gerontol 50:P187–192 Nordin S, Monsch AU, Murphy C (1995) Unawareness of smell loss in normal aging and Alzheimer’s disease: discrepancy between self-reported and diagnosed smell sensitivity. J Gerontol 50:P187–192
21.
go back to reference Nordin S, Murphy C, Davidson TM, Quinonez C, Jalowayski AA, Ellison DW (1996) Prevalence and assessment of qualitative olfactory dysfunction in different age groups. Laryngoscope 106:739–744 Nordin S, Murphy C, Davidson TM, Quinonez C, Jalowayski AA, Ellison DW (1996) Prevalence and assessment of qualitative olfactory dysfunction in different age groups. Laryngoscope 106:739–744
22.
go back to reference Quint C, Temmel AF, Schickinger B, Pabinger S, Ramberger P, Hummel T (2001) Patterns of non-conductive olfactory disorders in eastern Austria: a study of 120 patients from the Department of Otorhinolaryngology at the University of Vienna. Wien Klin Wochenschr 113:52–57 Quint C, Temmel AF, Schickinger B, Pabinger S, Ramberger P, Hummel T (2001) Patterns of non-conductive olfactory disorders in eastern Austria: a study of 120 patients from the Department of Otorhinolaryngology at the University of Vienna. Wien Klin Wochenschr 113:52–57
23.
go back to reference Stevens JC, Cain WS (1986) Smelling via the mouth: effect of aging. Percept Psychophys 40:142–146 Stevens JC, Cain WS (1986) Smelling via the mouth: effect of aging. Percept Psychophys 40:142–146
24.
go back to reference Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128:635–641 Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128:635–641
25.
go back to reference Ware JE (1996) The SF-36 Health Survey. In: Spilker B (ed) Quality of life and pharmaeconomics in clinical trials. Lipincott-Raven, Philadelphia:, pp 337–346 Ware JE (1996) The SF-36 Health Survey. In: Spilker B (ed) Quality of life and pharmaeconomics in clinical trials. Lipincott-Raven, Philadelphia:, pp 337–346
26.
go back to reference Wolfensberger M, Schnieper I, Welge-Lussen A (2000) Sniffin’Sticks: a new olfactory test battery. Acta Otolaryngol 120:303–306 Wolfensberger M, Schnieper I, Welge-Lussen A (2000) Sniffin’Sticks: a new olfactory test battery. Acta Otolaryngol 120:303–306
27.
go back to reference Wysocki CJ, Gilbert AN (1989) National Geographic Smell Survey: effects of age are heterogenous. Ann N Y Acad Sci 561:12–28 Wysocki CJ, Gilbert AN (1989) National Geographic Smell Survey: effects of age are heterogenous. Ann N Y Acad Sci 561:12–28
28.
go back to reference Zarinko K (1896) Über Kakosmia subjectiva. In: Festschrift zur Feier des 80-jährigen Stiftungsfestes des ärztlichen Vereins zu Hamburg. Leipzig, pp 339–342 Zarinko K (1896) Über Kakosmia subjectiva. In: Festschrift zur Feier des 80-jährigen Stiftungsfestes des ärztlichen Vereins zu Hamburg. Leipzig, pp 339–342
29.
go back to reference Zerssen D (1975) Die Befindlichkeitsskala. Beltz Test, Göttingen Zerssen D (1975) Die Befindlichkeitsskala. Beltz Test, Göttingen
30.
go back to reference Zilstorff K (1966) Parosmia. J Laryngol 80:1102–1104 Zilstorff K (1966) Parosmia. J Laryngol 80:1102–1104
Metadata
Title
Olfactory dysfunction and daily life
Authors
Johannes Frasnelli
Thomas Hummel
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 3/2005
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-004-0796-y

Other articles of this Issue 3/2005

European Archives of Oto-Rhino-Laryngology 3/2005 Go to the issue