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European Archives of Oto-Rhino-Laryngology

Published in:

01-03-2006 | Head and Neck Oncology

Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Authors: Heung-Man Lee, Seung-Kuk Baek, Soon-Young Kwon, Kwang-Yoon Jung, Sung-Won Chae, Soon-Jae Hwang, Jeong-Soo Woo, June-Young Lee

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2006

Abstract

We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

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Title: Cyclooxygenase 1 and 2 expressions in the human thyroid gland
Authors: Heung-Man Lee
Seung-Kuk Baek
Soon-Young Kwon
Kwang-Yoon Jung
Sung-Won Chae
Soon-Jae Hwang
Jeong-Soo Woo
June-Young Lee
Publication date: 01-03-2006
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2006
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-005-0999-x

At a glance: The STEP trials

Springer Medicine

Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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