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Archives of Gynecology and Obstetrics

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01-12-2019 | Trisomy 18 | Maternal-Fetal Medicine

First trimester uterine artery pulsatility index levels in euploid and aneuploid pregnancies

Authors: Natalia Prodan, Philipp Wagner, Jiri Sonek, Markus Hoopmann, Armin Mutz, Sara Brucker, Karl Oliver Kagan

Published in: Archives of Gynecology and Obstetrics | Issue 6/2019

Abstract

Objective

To examine whether the uterine artery PI is different in aneuploid and euploid pregnancies.

Methods

Retrospective case-matched study at the department of prenatal medicine at the University of Tuebingen, Germany. The study involved patients with complete data on first trimester screening for trisomies and preeclampsia except PlGF. For each case with trisomy 21 we randomly selected 50 cases with a euploid fetus where complete data on screening for aneuploidy and preeclampsia were also available. The uterine artery pulsatility index and the corresponding MoM values of euploid and the aneuploid population were compared with a Man–Whitney U test.

Results

The dataset consisted of 4591 singleton pregnancies. The karyotype was normal in 4500 cases and was abnormal in the remaining 91 pregnancies. There were 50 pregnancies with trisomy 21, 31 with trisomy 18 and 13, and 10 with triploidy. In the group with euploid fetuses, median uterine artery PI was 1.55 (0.99 MoM). In the group with trisomy 21, the median PI (1.42) and MoM (0.89) levels were both significantly lower than in the euploid (p < 0.001). However, the measurements in the trisomy 18 and 13 [1.61 (0.93 MoM)] and in the triploidy [1.99 (1.13 MoM)] groups were not significantly different from those in the euploid group (p = 0.468 and p = 0.632, respectively).

Conclusion

In conclusion, uterine artery PI levels in the first trimester are slightly lower in pregnancies with trisomy 21. This knowledge may prove to be useful in cases where a low PAPP-A level is seen on the first trimester maternal serum biochemical evaluation to differentiate whether the more likely cause for this finding is placental dysfunction or aneuploidy, specifically trisomy 21.

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Title: First trimester uterine artery pulsatility index levels in euploid and aneuploid pregnancies
Authors: Natalia Prodan
Philipp Wagner
Jiri Sonek
Markus Hoopmann
Armin Mutz
Sara Brucker
Karl Oliver Kagan
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Trisomy 18
Trisomy 21
Trisomy
Pre-Eclampsia
Published in: Archives of Gynecology and Obstetrics / Issue 6/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05328-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

First trimester uterine artery pulsatility index levels in euploid and aneuploid pregnancies

Abstract

Objective

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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