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Archives of Gynecology and Obstetrics

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01-09-2019 | Premature Rupture of Membranes | Maternal-Fetal Medicine

Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies

Authors: Giovanni Sisti, Sara Paccosi, Astrid Parenti, Viola Seravalli, Mariarosaria Di Tommaso, Steven S. Witkin

Published in: Archives of Gynecology and Obstetrics | Issue 3/2019

Abstract

Purpose

Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins.

Methods

In this prospective study peripheral blood was obtained from 58 women with twin gestations prior to 20 weeks gestation and sera analyzed by ELISA for concentrations of IGFBP-1. Demographic and clinical outcome data were subsequently obtained and associations between IGFBP-1 and PPROM were analyzed by the Mann–Whitney test and receiver operator curve (ROC) analysis.

Results

Eight of our subjects developed PPROM. They did not differ from the other women in demographics, medical history or current pregnancy outcome parameters. However, median IGFBP-1 levels were higher in women who subsequently developed PPROM (59.3 ng/ml) than in the other women (46.6 ng/ml) (p = 0.042). Using a cutoff value of 53.9 ng/ml the circulating IGFBP-1 level predicted development of PPROM with a sensitivity of 74%, specificity of 75%, a negative predictive value of 97% and a positive predictive value of 20%.

Conclusions

Pending validation in larger studies the findings suggest that determination of serum IGFBP-1 levels in women with twin pregnancies may predict the later development of PPROM.

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Title: Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies
Authors: Giovanni Sisti
Sara Paccosi
Astrid Parenti
Viola Seravalli
Mariarosaria Di Tommaso
Steven S. Witkin
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keywords: Premature Rupture of Membranes
Insulins
Insulins
Published in: Archives of Gynecology and Obstetrics / Issue 3/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05214-9

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Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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