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Archives of Gynecology and Obstetrics

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01-08-2019 | Biomarkers | Gynecologic Endocrinology and Reproductive Medicine

Serum and follicular fluid Stem Cell Factor assay in IVF poor responder and normal responder patients: a predictive biomarker of oocyte retrieval

Authors: Mauro Cozzolino, Maria Cruz, Azadeh Patel, Jayesh Patel, Alberto Pacheco, Juan Antonio Garcia-Velasco

Published in: Archives of Gynecology and Obstetrics | Issue 2/2019

Abstract

Objective

The aim of the study is to investigate serum stem cell factor (SCF) concentrations as potential biomarker for oocyte retrieval efficiency in IVF patients with poor prognosis.

Methods

A pilot case–control study was performed on 30 poor and 30 normal responders that were stimulated with antagonist protocol. SCF concentrations were evaluated in samples of serum and follicular fluid obtained by all patients on the day of oocyte retrieval. At the time of oocyte retrieval, follicular fluid from at least two follicles ≥ 14 mm and two follicles < 14 mm was collected for SCF determination.

Results

We did not find any statistical difference when comparing serum and follicular fluid levels of SCF in both poor- and normal-responder patients, the same results were achieved when poor-responder patients were stratified according to the number of MII oocytes retrieved. Moreover, levels of SCF (OR 1.000, 0.994–1.006) or in follicular fluid from ovarian follicles ≥ 14 mm (OR 0.995, CI 0.989–1.001) or from ovarian follicles < 14 mm (OR 1.003, CI 0.999–1.0069), were not significantly associated with the chances of ongoing pregnancies in poor-responder patients.

Conclusion

SCF was unable to predict oocyte retrieval efficiency or the chances of reaching embryo transfer.

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Title: Serum and follicular fluid Stem Cell Factor assay in IVF poor responder and normal responder patients: a predictive biomarker of oocyte retrieval
Authors: Mauro Cozzolino
Maria Cruz
Azadeh Patel
Jayesh Patel
Alberto Pacheco
Juan Antonio Garcia-Velasco
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keyword: Biomarkers
Published in: Archives of Gynecology and Obstetrics / Issue 2/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05172-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum and follicular fluid Stem Cell Factor assay in IVF poor responder and normal responder patients: a predictive biomarker of oocyte retrieval

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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