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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 5/2019

01-05-2019 | Preterm Labor | Maternal-Fetal Medicine

Second-trimester maternal lipid profiles predict pregnancy complications in an age-dependent manner

Authors: Qi Wu, Lixia Zhang, Licong Huang, Yu Lei, Lin Chen, Zhaoxia Liang, Menglin Zhou, Heng Xu, Yumei Zhou, Fei Wang, Danqing Chen

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

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Abstract

Purpose

Our objective was to investigate the combinatorial effect of maternal age and second-trimester maternal lipid profiles for pregnancy complications.

Methods

With 1:4 matching, this retrospective study selected 499 advanced maternal age women and 1996 younger controls. Logistic regression analysis was used to estimate the correlation between second-trimester lipid profiles [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] and pregnancy complications [gestational diabetes mellitus (GDM), pregnancy-induced hypertension syndrome (PIH), preterm labor (PTL), and macrosomia]. Optimal cutoff points were determined by ROC curve analysis.

Results

In women aged 20–34 years, TG are a risk factor for PIH (OR 1.54, 95% CI 1.16–2.04) and PTL (OR 1.34, 95% CI 1.04–1.72). LDL-C was positively associated with macrosomia (OR 1.25, 95% CI 1.04–1.50), while HDL-C was negatively associated with PIH (OR 0.45, 95% CI 0.21–0.93). The optimal cutoff points for TG predicting PIH and PTL were separately ≥ 2.135 and 2.305 mmol/L. The optimal cutoff point for HDL-C identifying PIH was ≤ 1.995 mmol/L and for LDL-C identifying macrosomia was ≥ 3.425 mmol/L. As for advanced maternal age, only TG was an independent risk factor for PIH (OR 1.60, 95% CI 1.01–2.54), and its optimal cutoff point was ≥ 2.375 mmol/L.

Conclusions

Second-trimester lipid profiles might predict pregnancy complications varied by maternal age. This suggested that individualized prenatal care strategies should be established for women with advanced and normal maternal age to prevent pregnancy complications.
Appendix
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Metadata
Title
Second-trimester maternal lipid profiles predict pregnancy complications in an age-dependent manner
Authors
Qi Wu
Lixia Zhang
Licong Huang
Yu Lei
Lin Chen
Zhaoxia Liang
Menglin Zhou
Heng Xu
Yumei Zhou
Fei Wang
Danqing Chen
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Keyword
Preterm Labor
Published in
Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-019-05094-z

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