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Archives of Gynecology and Obstetrics

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01-04-2019 | Miscarriage | Maternal-Fetal Medicine

Obstetrical outcomes of embryo reduction and fetal reduction compared to non-reduced twin pregnancies

Authors: Mi Sun Kim, Sukho Kang, Eun Duc Na, Jisun Im, Eunhee Ahn, Ji Eun Shin, Myoung Jin Moon

Published in: Archives of Gynecology and Obstetrics | Issue 4/2019

Abstract

Purpose

To prevent perinatal morbidity and mortality of high-order multiple pregnancy (HOMP), multifetal pregnancy reduction (MPR) is offered to some patients. In this study, we investigated whether twin pregnancies derived from MPRs carry a higher adverse obstetrical outcome compared to non-reduced control group of twins.

Methods

We retrospectively analyzed the data from HOMPs on which transvaginal ER (n = 153) at a mean gestational age of 7.6 weeks or transabdominal FR (n = 59) at a mean gestational age of 12.4 weeks was performed between December 2006 and January 2018. The risk of each procedure was evaluated by comparing obstetrical outcome with that of a control population of 157 non-reduced twins conceived by infertility treatment.

Results

The mean gestational ages at delivery were 35.2 weeks in the ER group, 35.7 weeks in the FR group, and 34.1 weeks in the control group (P = NS). Compared with those in the control group, the ER group had higher miscarriage (1.3% vs. 6.5%; P = 0.047; OR 0.21; 95% CI 0.45–0.898) and higher overall fetal loss (3.8% vs. 14.4%; P = 0.003; OR 0.24; 95% CI 0.09–0.60) rates. Differently compared with those in the control group, the FR group had no statistical difference in miscarriage (2.5% vs. 1.7%; P=NS) and overall fetal loss (3.8% vs. 6.8%; P=NS) rates.

Conclusions

Compared with the control group, ER in twins had a higher miscarriage and fetal loss rate, whereas FR in twins was similar to the control group. So, the FR procedure is overall a better and safer approach of MPR in reducing morbidity and mortality in HOMPs.

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Title: Obstetrical outcomes of embryo reduction and fetal reduction compared to non-reduced twin pregnancies
Authors: Mi Sun Kim
Sukho Kang
Eun Duc Na
Jisun Im
Eunhee Ahn
Ji Eun Shin
Myoung Jin Moon
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keywords: Miscarriage
Multiple Pregnancy
Published in: Archives of Gynecology and Obstetrics / Issue 4/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05089-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Obstetrical outcomes of embryo reduction and fetal reduction compared to non-reduced twin pregnancies

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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