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01-03-2019 | Human Papillomavirus | Gynecologic Oncology

Rates of regression of cervical dysplasia between initial biopsy and excisional procedure in routine clinical practice

Authors: Katrina Mark, Anja Frost, Heather Hussey, Micael Lopez-Acevedo, Anne E. Burke, Jill Edwardson, Opey Solaru, Patti Gravitt

Published in: Archives of Gynecology and Obstetrics | Issue 3/2019

Abstract

Purpose

To determine rates and factors associated with regression of cervical intraepithelial neoplasia (CIN) 2 + between colposcopic biopsy and therapeutic excisional procedure in standard practice.

Methods

A retrospective chart review was performed for women undergoing a cervical excisional procedure for CIN 2 + at clinics at three academic institutions over a 3-year period. Cytology, histology, patient age and time-to-excision were analyzed to determine factors influencing rates of regression.

Results

Of 356 women undergoing excision for CIN 2 + on colposcopic biopsy, 91 (25.3%) of final pathology diagnoses displayed clinically significant regression. Age and time-to-excision were not associated with regression, but referral cytology and severity of initial biopsy histology were, with ASC-H (aOR 0.1, CI 0.03, 0.8) and CIN 3/AIS (aOR 0.4, CI 0.2, 0.7) being less likely to regress than less severe lesions.

Conclusions

Disease severity by referral cytology or diagnostic biopsy, as opposed to age or length of time-to-excision, is likely the most relevant factor in determination of regression for cervical intraepithelial neoplasia in women undergoing excisional treatment for biopsy-confirmed CIN2 +.

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Title: Rates of regression of cervical dysplasia between initial biopsy and excisional procedure in routine clinical practice
Authors: Katrina Mark
Anja Frost
Heather Hussey
Micael Lopez-Acevedo
Anne E. Burke
Jill Edwardson
Opey Solaru
Patti Gravitt
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Human Papillomavirus
Colposcopy
Colposcopy
Published in: Archives of Gynecology and Obstetrics / Issue 3/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-5026-8

ACC 2024 Congress

Springer Medicine

Rates of regression of cervical dysplasia between initial biopsy and excisional procedure in routine clinical practice

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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