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Archives of Gynecology and Obstetrics

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01-04-2018 | General Gynecology

Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

Authors: Fangchao Mei, Teng Zuo, Liang Zhao, Qiao Shi, Mingwei Xiang, Yupu Hong, Man Li, Weixing Wang

Published in: Archives of Gynecology and Obstetrics | Issue 4/2018

Abstract

Objective

The objective of this study was to determine the mechanism of acute renal injury (ARI) in acute necrotizing pancreatitis in late pregnancy (ANPIP).

Methods

Pregnant Sprague–Dawley rats in the third trimester were used for this study, and an ANPIP model was induced by injecting 5% sodium taurocholate into the biliary pancreatic duct. The rats were randomly divided into three groups: the normal, sham-operated (SO) and acute necrotizing pancreatitis (ANP) groups. Rats were killed at 3, 6, 12 h after the operation, and blood, pancreatic and renal tissue samples were harvested. Differences were detected in the physiology, pathology and cellular and molecular responses among the different groups.

Result

Serum amylase, lipase, urea and Cr levels were increased in rats with ANPIP. Additionally, expression of phosphorylation p38 and JNK as well as TNF-α and NF-κB were increased in the renal tissues of rats with ANPIP. The expression of phosphorylation ERK was decreased in the renal tissues of rats with ANPIP.

Conclusions

Mitogen-activated protein kinases may play an important role in renal injury in rat models of ANPIP.

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Title: Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy
Authors: Fangchao Mei
Teng Zuo
Liang Zhao
Qiao Shi
Mingwei Xiang
Yupu Hong
Man Li
Weixing Wang
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4668-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

Abstract

Objective

Methods

Result

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Methods

Result

Conclusions

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