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01-02-2018 | Maternal-Fetal Medicine

Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development

Authors: Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Cristina Gutierrez-Arteaga, Ivan Delgado-Enciso, Olga Y. Barbosa-Cisneros, Virginia Flores-Morales, Gloria P. Hernandez-Delgadillo, Maria R. Rocha-Pizaña, Iram P. Rodriguez-Sanchez, Jose I. Badillo-Almaraz, Jose M. Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Luis O. Solis-Sanchez, Yolanda Ortiz-Castro

Published in: Archives of Gynecology and Obstetrics | Issue 2/2018

Abstract

Purpose

To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development.

Methods

Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates.

Results

A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE (P = 0.007).

Conclusions

Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.

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Title: Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
Authors: Margarita L. Martinez-Fierro
Idalia Garza-Veloz
Cristina Gutierrez-Arteaga
Ivan Delgado-Enciso
Olga Y. Barbosa-Cisneros
Virginia Flores-Morales
Gloria P. Hernandez-Delgadillo
Maria R. Rocha-Pizaña
Iram P. Rodriguez-Sanchez
Jose I. Badillo-Almaraz
Jose M. Ortiz-Rodriguez
Rodrigo Castañeda-Miranda
Luis O. Solis-Sanchez
Yolanda Ortiz-Castro
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4611-6

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Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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