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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 3/2017

01-09-2017 | Review

Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes

Authors: Joseph Zikry, Dorota Z. Korta, Lance W. Chapman, Kenneth G. Linden

Published in: Archives of Gynecology and Obstetrics | Issue 3/2017

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Abstract

Purpose

To assess the clinical presentation, treatment modalities, and outcome of primary melanomas arising in ovarian cystic teratomas (OCT).

Methods

A systematic review on PubMed/MEDLINE was performed on June 5, 2017, to gather data on patients with primary melanomas arising in OCTs. No systematic reviews were identified. Consequently, only case reports and case series of individuals were analyzed. A total of 37 articles met our inclusion criteria, totaling 41 unique patients.

Results

The average age of diagnosis was 51.5 years. In total, 24% of patients were found to have metastatic disease. In total, 56.7% of patients eventually died of their disease, with an average time from diagnosis to death of 9.3 months. Disease recurrence was common, occurring in 65% of patients. The mainstay of treatment was surgical in 100% of the cases. Adjuvant chemotherapy, immunotherapy, and radiation were also used with varying degrees of efficacy.

Conclusions

Malignant melanoma arising in OCT is a rare disease with poor prognosis. The current mainstay treatment is surgical. Potential benefits of targeted therapy, immunotherapy, and chemotherapy remain to be determined. A limitation of this study is that these melanomas have only been published in case reports.
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Metadata
Title
Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes
Authors
Joseph Zikry
Dorota Z. Korta
Lance W. Chapman
Kenneth G. Linden
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 3/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4437-2

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