Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 3/2017

01-09-2017 | Gynecologic Oncology

Association between ERCC2 rs13181 polymorphism and ovarian cancer risk: an updated meta-analysis with 4024 subjects

Authors: JieNa Li, Lei Pan, Xia Qin, HongYan Chu, HuiYing Mu, GuoXing Wan

Published in: Archives of Gynecology and Obstetrics | Issue 3/2017

Login to get access

Abstract

Background

Genetic variants in the excision repair cross-complimentary group 2 (ERCC2) gene may affect individual susceptibility to cancer by modulating the capability of DNA damage repair. However, the current studies concerning the association of ERCC2 rs13181 polymorphism with ovarian cancer risk provided inconsistent evidence.

Methods

This study was to quantitatively summarize the evidence from the individual studies electronically retrieved by a meta-analysis.

Results

Totally, nine eligible case–control studies with 1333 cases and 2691 controls were included for the concerned association. Overall, a significant association between ERCC2 gene rs13181 polymorphism and increased risk of ovarian cancer was revealed (CC+AC vs. AA: OR 1.44, 95% CI 1.11–1.86; CC vs. AA: OR 2.12, 95% CI 1.14–3.97). Similarly, in the subgroup analyses, such association was also evident in non-Caucasian population and hospital-based studies. Noteworthily, the recombined analysis with a significant decrease in between-heterogeneity represented a significant association of the variant with increased risk of ovarian cancer after excluding the individual study not in agreement with HWE.

Conclusion

The present study suggests that the ERCC2 gene rs13181 polymorphism might be associated with increased risk of ovarian cancer.
Literature
1.
Jia HM, Zhang QY, Liu FX, Zhou DS (2017) Prognostic value of MMP-2 for patients with ovarian epithelial carcinoma: a systematic review and meta-analysis. Arch Gynecol Obstet 295(3):689–696CrossRefPubMed
2.
de Boer JG (2002) Polymorphisms in DNA repair and environmental interactions. Mutat Res 509(1–2):201–210CrossRefPubMed
3.
Ji G, Gu A, Zhou Y, Shi X, Xia Y, Long Y, Song L, Wang S, Wang X (2010) Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PLoS One 5(10):e13145CrossRefPubMedPubMedCentral
4.
Mouw KW, D’Andrea AD, Konstantinopoulos PA (2015) Nucleotide excision repair (NER) alterations as evolving biomarkers and therapeutic targets in epithelial cancers. Oncoscience 2(12):942–943PubMedPubMedCentral
5.
Liu D, Wu D, Li H, Dong M (2014) The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis. Gene 538(2):209–216CrossRefPubMed
6.
Coin F, Marinoni JC, Rodolfo C, Fribourg S, Pedrini AM, Egly JM (1998) Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. Nat Genet 20(2):184–188CrossRefPubMed
7.
Wu KG, He XF, Li YH, Xie WB, Huang X (2014) Association between the XPD/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case–control studies. Tumour Biol 35(11):11243–11259CrossRefPubMed
8.
Costa S, Pinto D, Pereira D, Vasconcelos A, Afonso-Lopes C, Osorio T, Lopes C, Medeiros R (2007) Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer. Cancer Lett 246(1–2):324–330CrossRefPubMed
9.
10.
11.
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748PubMed
12.
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101CrossRefPubMed
13.
14.
Michalska MM, Samulak D, Romanowicz H, Sobkowski M, Smolarz B (2015) An association between single nucleotide polymorphisms of Lys751Gln ERCC2 gene and ovarian cancer in Polish women. Adv Med 2015:109593CrossRefPubMedPubMedCentral
15.
Khokhrin DV, Khrunin AV, Moiseev AA, Gorbunov VA, Limborskaia SA (2012) Association of polymorphisms in glutathione-S-transferase and DNA repair genes with ovarian cancer risk in the Russian population. Russ J Genet 48(7):764–766CrossRef
16.
Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Toloczko-Grabarek A, Gilbert M, Edler L, Zapatka M, Eils R, Lubinski J, Scott RJ, Hamann U (2010) BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms. Breast Cancer Res Treat 119(1):201–211CrossRefPubMed
17.
Bernard-Gallon D, Bosviel R, Delort L, Fontana L, Chamoux A, Rabiau N, Kwiatkowski F, Chalabi N, Satih S, Bignon YJ (2008) DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk. Mol Cancer 7:36CrossRefPubMedPubMedCentral
18.
Mohamed FZ, Hussien YM, AlBakry MM, Mohamed RH, Said NM (2013) Role of DNA repair and cell cycle control genes in ovarian cancer susceptibility. Mol Biol Rep 40(5):3757–3768CrossRefPubMed
19.
Xing YP (2007) The correlation of DNA repair gene XPD polymorphisms to ovarian cancer. J Hebei Med Univ 38(5):S12–S17 (article in Chinese)
20.
Monteiro MS, Vilas BD, Gigliotti CB, Salvadori DM (2014) Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer. Genet Mol Res 13(1):636–648CrossRefPubMed
21.
Yildirim G, Attar R, Fiçicioglu C, Gulec-Yilmaz S, Timirci-Kahraman O, Atasoy H, Yildirim OK, Iyibozkurt C, Buyukoren A, Dalan AB, Çakmakoğlu B, Ergen A, Isbir T (2014) Association between ERCC2 gene polymorphism and primary ovarian cancer. Anticancer Res 34:5966–5967
22.
Duell EJ, Wiencke JK, Cheng TJ, Varkonyi A, Zuo ZF, Ashok TD, Mark EJ, Wain JC, Christiani DC, Kelsey KT (2000) Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21(5):965–971CrossRefPubMed
23.
Peng Q, Li S, Lao X, Chen Z, Li R, Qin X (2014) Association between XPD Lys751Gln and Asp312Asn polymorphisms and hepatocellular carcinoma risk: a systematic review and meta-analysis. Medicine (Baltimore) 93(29):e330CrossRef
24.
Taylor EM, Broughton BC, Botta E, Stefanini M, Sarasin A, Jaspers NG, Fawcett H, Harcourt SA, Arlett CF, Lehmann AR (1997) Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene. Proc Natl Acad Sci USA 94(16):8658–8663CrossRefPubMedPubMedCentral
25.
Hou SM, Falt S, Angelini S, Yang K, Nyberg F, Lambert B, Hemminki K (2002) The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis 23(4):599–603CrossRefPubMed
26.
Yu XW, Wei ZT, Li YY, Wang B, Mi C, Xing AY, Hu C (2016) Association between ERCC2 rs13181 and XRCC2 rs3218536 polymorphisms and the risk of ovarian cancer: a meta-analysis. Int J Clin Exp Med 9(2):1558–1566
27.
Zhang W, Zhang Z (2016) Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer. Oncotarget 7(52):86621–86629PubMedPubMedCentral
Metadata
Title
Association between ERCC2 rs13181 polymorphism and ovarian cancer risk: an updated meta-analysis with 4024 subjects
Authors
JieNa Li
Lei Pan
Xia Qin
HongYan Chu
HuiYing Mu
GuoXing Wan
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 3/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4443-4

Other articles of this Issue 3/2017

Archives of Gynecology and Obstetrics 3/2017 Go to the issue

General Gynecology

Hysterectomy technique and risk of pelvic organ prolapse repair: a Danish nationwide cohort study

Maternal-Fetal Medicine

Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia?

Maternal-Fetal Medicine

Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes

Correspondence

Spontaneous rupture of infarcted leiomyoma into endometrial cavity in a perimenopausal woman

Gynecologic Oncology

Subserosal uterine injection of blue dye for the identification of the sentinel node in patients with endometrial cancer: a feasibility study

General Gynecology

Emergence of Candida glabrata in vulvovaginal candidiasis should be attributed to selective pressure or virulence ability?