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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 2/2017

01-02-2017 | Review

Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis

Authors: Jia-Bi Qin, Xiao-Qi Sheng, Di Wu, Shi-You Gao, Yi-Ping You, Tu-Bao Yang, Hua Wang

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

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Abstract

Purpose

The worldwide prevalence of adverse pregnancy outcomes (APOs) in singleton pregnancies after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) is suggested to vary; however, a complete overview is missing. The aim of this review is to estimate the worldwide prevalence of APOs associated with IVF/ICSI singleton pregnancies.

Methods

PubMed, Google Scholar, Cochrane Libraries, and Chinese databases were searched for studies assessing APOs among IVF/ICSI singleton births through March 2016. The prevalence estimates were summarized and analyzed by meta-analysis.

Results

Fifty-two cohort studies, with 181,741 IVF/ICSI singleton births and 4,636,508 spontaneously conceived singleton births, were selected for analysis. Among IVF/ICSI singleton pregnancies, pooled estimates were 10.9% [95% confidence interval (CI) 10.0–11.8] for preterm birth, 2.4% (95% CI 1.9–3.0) for very preterm birth, 8.7% (95% CI 7.4–10.2) for low birth weight, 2.0% (95% CI 1.5–2.6) for very low birth weight, 7.1% (95% CI 5.5–9.2) for small for gestational age, 1.1% (95% CI 0.9–1.3) for perinatal mortality, and 5.7% (95% CI 4.7–6.9) for congenital malformations. The IVF/ICSI singleton pregnancies have higher prevalence of APOs compared with those conceived naturally (all P = 0.000). Significant differences in different continents, countries, income groups, and type of assisted conception were found.

Conclusions

The IVF/ICSI singleton pregnancies are at a higher prevalence of adverse perinatal outcomes compared with those conceived naturally. Important geographical differences were found. Yet, population-wide prospective APO registries covering the entire world population for IVF/ICSI pregnancies are needed to determine the exact perinatal prevalence.
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Metadata
Title
Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis
Authors
Jia-Bi Qin
Xiao-Qi Sheng
Di Wu
Shi-You Gao
Yi-Ping You
Tu-Bao Yang
Hua Wang
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4250-3

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