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Archives of Gynecology and Obstetrics

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01-03-2017 | General Gynecology

Elevated RON protein expression in endometriosis and disease-associated ovarian cancers

Authors: Ping Xu, Shaojie Ding, Libo Zhu, Fang Le, Xiufeng Huang, Yonghong Tian, Xinmei Zhang

Published in: Archives of Gynecology and Obstetrics | Issue 3/2017

Abstract

Background

Recepteur d’origine nantais (RON) protein expression has been demonstrated to correlate with tumor progression, metastasis, and prognosis, and its mRNA expression increases in deeply infiltrating endometriotic lesions. However, it remains unclear whether RON protein expression also increases in endometriotic lesions, and may be a risk factor of malignant transformation in endometriotic lesions.

Methods

The protein expression of RON in control (n = 19), eutopic (n = 16), and ectopic (n = 51) endometria, as well as in endometriosis-associated ovarian cancers (EAOC, n = 16) was determined by immunohistochemical (IHC) staining.

Results

Endometriotic lesions expressed low levels of RON protein, but no RON protein expression appeared in matched eutopic or control endometrium. EAOC exhibited high levels of RON protein. The frequency and IHC score of RON protein expression were both significantly higher in EAOC [100.0% (14/14), 5.37 ± 0.74] than those in endometriotic lesions [51.0% (26/51), 2.15 ± 1.12; P = 0.002, 0.001]. Multivariate analysis of covariance only revealed a correlation of RON protein expression and EAOC (P = 0.006), but no correlations of RON protein expression and clinical parameters (P > 0.05).

Conclusions

These obtained results suggest that increased RON expression might be involved in the pathogenesis of endometriosis and disease-associated ovarian cancers.

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Title: Elevated RON protein expression in endometriosis and disease-associated ovarian cancers
Authors: Ping Xu
Shaojie Ding
Libo Zhu
Fang Le
Xiufeng Huang
Yonghong Tian
Xinmei Zhang
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4248-x

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Springer Medicine

Elevated RON protein expression in endometriosis and disease-associated ovarian cancers

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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